Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Marshall, Christian R., Howrigan, Daniel P., Merico, Daniele, Thiruvahindrapuram, Bhooma, Wu, Wenting, Greer, Douglas S., Antaki, Danny, Shetty, Aniket, Holmans, Peter A. ORCID: https://orcid.org/0000-0003-0870-9412, Pinto, Dalila, Gujral, Madhusudan, Brandler, William M., Malhotra, Dheeraj, Wang, Zhouzhi, Fuentes Fajarado, Karin V., Maile, Michelle S., Ripke, Stephan, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amin, Farooq, Atkins, Joshua, Bacanu, Silviu A., Belliveau Jr., Richard A., Bergen, Sarah E., Bertalan, Marcelo, Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Bulik-Sullivan, Brendan, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Carins, Murray J., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa ORCID: https://orcid.org/0000-0003-0739-0382, Catts, Stanley V., Chambert, Kimberley D., Cheng, Wei, Cloninger, C. 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Scott, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Thirumalai, Srinivas, Tooney, Paul A., Veijola, Juha, Visscher, Peter M., Waddington, John, Walsh, Dermot, Webb, Bradley T., Weiser, Mark, Wildneauer, Dieter B., Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Williams, Stephanie ORCID: https://orcid.org/0000-0003-1177-6931, Witt, Stephanie H., Wolen, Aaron R, Wormlet, Brandon K., Wray, Naomi R., Wu, Jing Qin, Zai, Clement C., Aldofsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H. R., Bramon, Elvira, Buxbaum, Joseph D., Cichon, Sven, Collier, David A., Corvin, Aiden, Daly, Mark J., Darvasi, Ariel, Domenici, Enrico, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Knight, JO, Levinson, Douglas F., Li, Qingqin S., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sklar, Pamela, St Clair, David, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Werge, Thomas, Sullivan, Patrick F., O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Scherer, Stephen W., Neale, Benjamin M. and Sebat, Jonathan 2017. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 49 , pp. 27-35. 10.1038/ng.3725

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Abstract

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (OR=1.11, P=5.7x10-15), which persisted after excluding loci implicated in previous studies (OR=1.07, P=1.7 x10-6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x10-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P= 7.3 x10-5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by non-allelic homologous recombination.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Genetics research Genomics Schizophrenia
Publisher:	Nature
ISSN:	1061-4036
Date of First Compliant Deposit:	10 November 2016
Date of Acceptance:	24 October 2016
Last Modified:	06 Nov 2024 05:30
URI:	https://orca.cardiff.ac.uk/id/eprint/96023

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