Browse by Current Cardiff authors

Woolway, Grace E., Legge, Sophie E., Lynham, Amy J., Smart, Sophie E. ORCID: https://orcid.org/0000-0002-6709-5425, Hubbard, Leon, Daniel, Ellie R., Pardiñas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, O’Donovan, Michael C., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Jones, Ian R. and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2024. Assessing the validity of a self-reported clinical diagnosis of schizophrenia. Schizophrenia 10 (1) , 99. 10.1038/s41537-024-00526-5

Shitomi-Jones, Lisa M., Dolman, Clare, Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Legge, Sophie E. and Di Florio, Arianna ORCID: https://orcid.org/0000-0003-0338-2748 2024. Exploration of first onsets of mania, schizophrenia spectrum disorders and major depressive disorder in perimenopause. nature mental health 2 (10) , pp. 1161-1168. 10.1038/s44220-024-00292-4

Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Woolway, Grace, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Cardno, Alastair G., Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael J. ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81 , pp. 681-690. 10.1001/jamapsychiatry.2024.0200

Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura, Andlauer, Till, von Scheidt, Moritz, Schizophrenia Working Group of the Psychiatric Genomics Consorti, Budde, Monika, Heilbronner, Urs, Papiol, Sergei, Teumer, Alexander, Homouth, Georg, Falkai, Peter, Volzke, Henry, Dorr, Marcus, Schulze, Thomas, Gagneur, Julien, Iorio, Francesco, Müller-Myhsok, Bertram, Schunkert, Heribert, Ziller, Michael, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379, Carrera, Noa ORCID: https://orcid.org/0000-0003-0739-0382, Craddock, Nicholas ORCID: https://orcid.org/0000-0003-2171-0610, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Georgieva, Lyudmila, Hamshere, Marian L. ORCID: https://orcid.org/0000-0002-8990-0958, Kavanagh, David, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Legge, Sophie, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Pocklington, Andrew ORCID: https://orcid.org/0000-0002-2137-0452, Richards, Alexander L., Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931 and Holmans, Peter A. ORCID: https://orcid.org/0000-0003-0870-9412 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15 , 5534. 10.1038/s41467-024-49338-2

Stevenson-Hoare, Joshua, Legge, Sophie E., Simmonds, Emily, Han, Jun, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 and Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27 (1) , e301097. 10.1136/bmjment-2024-301097

Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891, Simmonds, Emily, Pardiñas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Anney, Richard ORCID: https://orcid.org/0000-0002-6083-407X, Legge, Sophie E., Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Harrison, Neil A. ORCID: https://orcid.org/0000-0002-9584-3769, O’Donovan, Michael C. and Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 2024. Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational Psychiatry 14 , 194. 10.1038/s41398-024-02910-2

Jones, Rowena, Morales-Munoz, Isabel, Shields, Adrian, Blackman, Graham, Legge, Sophie E., Pritchard, Megan, Kornblum, Daisy, MacCabe, James H. and Upthegrove, Rachel 2023. Early neutrophil trajectory following clozapine may predict clozapine response ? Results from an observational study using electronic health records. Brain, Behavior, and Immunity 113 , pp. 267-274. 10.1016/j.bbi.2023.07.012

Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891, Legge, Sophie, Bracher-Smith, Matthew, Anney, Richard ORCID: https://orcid.org/0000-0002-6083-407X, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 and Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 2023. Copy Number Variants increasing risk for schizophrenia: shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry: Global Open Science 3 (4) , pp. 902-911. 10.1016/j.bpsgos.2022.10.006

Lock, Siobhan K., Legge, Sophie E., Kappel, Djenifer B., Willcocks, Isabella R. ORCID: https://orcid.org/0000-0002-3568-5236, Helthius, Marinka, Jansen, John, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Pardiñas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9 , 74. 10.1038/s41537-023-00404-6

Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, Legge, Sophie, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 and O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 2023. Genomic findings in schizophrenia and their implications. Molecular Psychiatry 28 , pp. 3638-3647. 10.1038/s41380-023-02293-8

Kappel, Djenifer B., Legge, Sophie E., Hubbard, Leon, Willcocks, Isabella R. ORCID: https://orcid.org/0000-0002-3568-5236, O'Connell, Kevin S., Smith, Robert L., Molden, Espen, Andreassen, Ole A., King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 and Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93 , pp. 149-156. 10.1016/j.biopsych.2022.07.014

Woolway, Grace, Smart, Sophie ORCID: https://orcid.org/0000-0002-6709-5425, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Lloyd, Jennifer, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889, Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 and Legge, Sophie 2022. Schizophrenia polygenic risk and experiences of childhood adversity: a systematic review and meta-analysis. Schizophrenia Bulletin 48 (5) , pp. 967-980. 10.1093/schbul/sbac049

Creeth, Hugo D. J., Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Legge, Sophie E., Dennison, Charlotte A. ORCID: https://orcid.org/0000-0002-7493-2041, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79 (10) , pp. 963-970. 10.1001/jamapsychiatry.2022.2289

Jones, Rowena, Upthegrove, Rachel, Price, Malcolm J., Pritchard, Megan, Chandan, Joht Singh, Legge, Sophie and MacCabe, James H. 2022. Duration of prior psychotic illness and clozapine response: a retrospective observational study using electronic health records. Therapeutic Advances in Psychopharmacology 12 , pp. 1-12. 10.1177/20451253221103353

Chambers, Tom, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Legge, Sophie, Baker, Emily, Singh, Krish ORCID: https://orcid.org/0000-0002-3094-2475, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891 and Anney, Richard J. L. ORCID: https://orcid.org/0000-0002-6083-407X 2022. Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular Psychiatry 27 , pp. 2282-2290. 10.1038/s41380-022-01443-8

Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862 and Legge, Sophie 2022. The nature of schizophrenia: as broad as it is long. Schizophrenia Research 242 , pp. 109-112. 10.1016/j.schres.2021.10.012

Trubetskoy, Vassily, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A. ORCID: https://orcid.org/0000-0002-7493-2041, Hall, Lynsey, Lam, Max, Watanabe, Kyoto, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Affonseca Bressan, Rodrigo, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angele, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., De Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fananas, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopa, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Ausrele Kučinskiene, Zita, Kusumawardhani, Agung, Kuzelov a-Ptackova, Hana, Land, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubiski, Jan, Luykx, Jurjen J., Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Macel Jr., Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihara, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Neuchterlein, Keith H., O'Brien, Niamh Louise, O'Neill, F. Anthony., Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitrou, George N., Paredella, Mara, Paurio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietilainen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veiko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Soderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes, Stogmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Stregman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Ucock, Alp, Vaaler, Arne, Van Amelsvoort, Therese, Van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J. ORCID: https://orcid.org/0000-0002-4357-574X, Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Ganda, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben, Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Indonesia Schizophrenia Consortium, PsychENCODE, Psychosis Endophenotypes International Consortium, The SynGO Consortium, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Borglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aidan, Curtis, David, Di Forti, Mara, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Esko, Tonu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jonsson, Erik G., Kahn, Rene S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S, Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQillin, Andrew, Menezes, Paolo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nothen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefansson, Hreinn, Stefansson, Kari, Tsuang, Ming T., Van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A. ORCID: https://orcid.org/0000-0003-0870-9412, Pocklington, Andrew ORCID: https://orcid.org/0000-0002-2137-0452, Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Schizophrenia Working Group of the Psychiatric Genomics Consorti 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604 , pp. 502-508. 10.1038/s41586-022-04434-5

Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., van Amelsvoort, T., Bartels-Velthuis, A. A., Bruggeman, R., Cahn, W., Guloksuz, S., de Haan, L., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., Alizadeh, B. Z., Luykx, J. J., Rutten, B. P. F., van Winkel, R., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F. ORCID: https://orcid.org/0000-0001-6845-7590, Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A. and Luykx, J. J. 2022. Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders. Translational Psychiatry 12 , 145. 10.1038/s41398-022-01884-3

Vassos, Evangelos, Kou, Jiaqi, Tosato, Sarah, Maxwell, Jessye, Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie, Walters, James ORCID: https://orcid.org/0000-0002-6980-4053, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379, Breen, Gerome, Lewis, Cathryn, Sullivan, Patrick, Hultman, Christina, Ruggeri, Mirella, Walshe, Muriel, Bramon, Elvira, Bergen, Sarah and Murray, Robin 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48 (1) , pp. 20-26. 10.1093/schbul/sbab052

Sanders, Bret, D'Andrea, Daniel, Collins, Mark O., Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Steward, Tom G. J., Zhu, Ying, Chapman, Gareth, Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Harwood, Adrian J. ORCID: https://orcid.org/0000-0003-3124-5169, Gray, William P. ORCID: https://orcid.org/0000-0001-7595-8887, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Errington, Adam C. ORCID: https://orcid.org/0000-0002-2171-389X, Blake, Derek J. ORCID: https://orcid.org/0000-0002-5005-4731, Whitcomb, Daniel J., Pocklington, Andrew J. ORCID: https://orcid.org/0000-0002-2137-0452 and Shin, Eunju ORCID: https://orcid.org/0000-0002-8865-6834 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13 (1) , 27. 10.1038/s41467-021-27601-0

Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Smart, Sophie ORCID: https://orcid.org/0000-0002-6709-5425, Willcocks, Isabella ORCID: https://orcid.org/0000-0002-3568-5236, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Legge, Sophie, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79 (3) , pp. 260-269. 10.1001/jamapsychiatry.2021.3799

Legge, Sophie E., Santoro, Marcos L., Periyasamy, Sathish, Okewole, Adeniran, Arsalan, Arsalan and Kowalec, Kaarina 2021. Genetic architecture of schizophrenia: a review of major advancements. Psychological Medicine 51 (13) 10.1017/S0033291720005334

Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie, Hubbard, Leon, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Cardno, Alastair, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47 (5) , pp. 1375-1384. 10.1093/schbul/sbab036

Legge, Sophie, Cardno, Alastair, Allardyce, Judith ORCID: https://orcid.org/0000-0003-4094-552X, Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Hubbard, Leon, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Richards, Alexander, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Di Florio, Arianna ORCID: https://orcid.org/0000-0003-0338-2748, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78 (10) , pp. 1143-1151. 10.1001/jamapsychiatry.2021.1961

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Willcocks, Isabella ORCID: https://orcid.org/0000-0002-3568-5236, Legge, Sophie, Nalmpanti, Mariana, Mazzeo, Lucy, King, Adrian, Jansen, John, Helthius, Marinka, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379, Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 and Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12 , 658734. 10.3389/fphar.2021.658734

Konte, Bettina, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Rujescu, Dan, Gieglin, Ina, Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Cohen, Dan, Pirmohamed, Munir, Tiihonen, Jari, Hartmann, Annette M., Bogers, Jan P., van der Weide, Jan, van der Weide, Karen, Putkonen, Anu, Repo-Tiihonen, Eila, Hallikainen, Tero, Silva, Ed, Ingimarsson, Oddur, Sigurdsson, Engilbert, Kennedy, James L., Sullivan, Patrick F., Rietschel, Marcella, Breen, Gerome, Stefansson, Hreinn, Stefansson, Kari, Collier, David A., O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Geigling, Ina 2021. HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. Translational Psychiatry 11 , 214. 10.1038/s41398-021-01322-w

Dennison, Charlotte A. ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie E., Bracher-Smith, Matthew, Menzies, Georgina ORCID: https://orcid.org/0000-0002-6600-6507, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Smith, Daniel J., Doherty, Aiden R., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16 (3) , e0249189. 10.1371/journal.pone.0249189

Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Kendall, Kimberley M. ORCID: https://orcid.org/0000-0002-6755-6121, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Legge, Sophie E., Bracher-Smith, Matthew, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2021. Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank. British Journal of Psychiatry 218 (2) , pp. 104-111. 10.1192/bjp.2020.139

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Legge, Sophie E., Christensen, Rune H., Petersen, Liselotte, Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Bracher-Smith, Matthew, Knapper, Steven, Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Hougaard, David M., Werge, Thomas, Nordentoft, Merete, Mortensen, Preben Bo, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Benros, Michael E. and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2020. The Duffy-null genotype and risk of infection. Human Molecular Genetics 29 (20) , pp. 3341-3349. 10.1093/hmg/ddaa208

Casetta, Cecilia, Oloyede, Ebenezer, Whiskey, Eromona, Taylor, David Michael, Gaughran, Fiona, Shergill, Sukhi S., Onwumere, Juliana, Segev, Aviv, Dzahini, Olubanke, Legge, Sophie E. and MacCabe, James Hunter 2020. A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis. British Journal of Psychiatry 217 (3) , pp. 506-513. 10.1192/bjp.2020.115

Grama, Steluta, Willcocks, Isabella ORCID: https://orcid.org/0000-0002-3568-5236, Hubert, John, Pardiñas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Legge, Sophie, Bracher-Smith, Matthew, Menzies, Georgina ORCID: https://orcid.org/0000-0002-6600-6507, Hall, Lynsey, Pocklington, Andrew ORCID: https://orcid.org/0000-0002-2137-0452, Anney, Richard ORCID: https://orcid.org/0000-0002-6083-407X, Bray, Nicholas ORCID: https://orcid.org/0000-0002-4357-574X, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 and Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10 , 309. 10.1038/s41398-020-00940-0

Legge, Sophie, Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Hopkins, Lucinda, Bates, Lesley, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216 (5) , pp. 259-266. 10.1192/bjp.2019.120

Richards, Alexander, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Frizzati, Aura ORCID: https://orcid.org/0000-0002-7002-6180, Tansey, Katherine, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Legge, Sophie, Savage, Jeanna, Agartz, Ingrid, Andreassen, Ole, Blokland, Gabriella, Corvin, Aiden, Cosgrove, Donna, Degenhardt, Franzoska, Djurovic, Srdjan, Espeseth, Thomas, Ferraro, Laura, Gayer-Anderson, Charlotte, Giegking, Ina, van Haren, Neeltje, Hartmann, Annette, Hubert, John, Jonsson, Erik, Konte, Bettina, Lennertz, Leonhard, Olde Loohuis, Loes, Melle, Ingrid, Morgan, Craig, Morris, Derek, Murray, Robin, Nyman, Håkan, Ophoff, Roel, van Os, Jim, Petryshen, Tracey, Quattrone, Diego, Rietschel, Marcella, Rujescu, Dan, Ruttan, Bart, Streit, Fabin, Strohmaier, Janna, Sullivan, Patrick, Sundet, Kjetil, Wagner, MIchael, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, Donohoe, Gary, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379, Walters, James ORCID: https://orcid.org/0000-0002-6980-4053, Schizophrenia Working Group of the Psychiatric Genomics Consorti and EUGEI WP Group 2020. The relationship between polygenic risk scores and cognition in schizophrenia. Schizophrenia Bulletin 46 (2) , -. 10.1093/schbul/sbz061

Dennison, Charlotte A. ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590 and Walters, James T.R. ORCID: https://orcid.org/0000-0002-6980-4053 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217 , pp. 4-12. 10.1016/j.schres.2019.10.048

Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, GROUP Investigators, Han, Jun, Morgan, Joanne, Carrera, Noa ORCID: https://orcid.org/0000-0003-0739-0382, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Pocklington, Andrew J. ORCID: https://orcid.org/0000-0002-2137-0452, Duffield, Madeleine, Hall, Lynsey S., Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Richards, Alexander L., Roth, Julian, Lezheiko, Tatyana, Kondratyev, Nikolay, Golimbat, Vera, Parellada, Mara, González-Peñas, Javier, Arango, Celso, Gawlik, Micha, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862 2020. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nature Neuroscience 23 (2) , pp. 179-184. 10.1038/s41593-019-0565-2

Legge, Sophie E., Jones, Hannah J., Kendall, Kimberley M. ORCID: https://orcid.org/0000-0002-6755-6121, Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Menzies, Georgina ORCID: https://orcid.org/0000-0002-6600-6507, Bracher-Smith, Matthew, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Davis, Katrina A., Hotopf, Matthew, Savage, Jeanne E., Posthuma, Danielle, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211 and Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053 2019. Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry 76 (12) , pp. 1256-1265. 10.1001/jamapsychiatry.2019.2508

Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Nalmpanti, Mariana, Pocklington, Andrew J. ORCID: https://orcid.org/0000-0002-2137-0452, Legge, Sophie E., Medway, Christopher ORCID: https://orcid.org/0000-0002-1764-0587, King, Adrian, Jansen, John, Helthuis, Marinka, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, MacCabe, James, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James T. R ORCID: https://orcid.org/0000-0002-6980-4053 2019. Pharmacogenomic variants and drug interactions identified through the genetic analysis of clozapine metabolism. American Journal of Psychiatry 176 (6) , pp. 477-486. 10.1176/appi.ajp.2019.18050589

Kendall, Kimberley M ORCID: https://orcid.org/0000-0002-6755-6121, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Bracher-Smith, Matthew, Legge, Sophie, Riglin, Lucy, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 and Walters, James Tynan Rhys ORCID: https://orcid.org/0000-0002-6980-4053 2019. Association of rare copy number variants with risk of depression. JAMA Psychiatry 76 (8) , pp. 818-825. 10.1001/jamapsychiatry.2019.0566

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Legge, Sophie E. and Walters, James T.R. ORCID: https://orcid.org/0000-0002-6980-4053 2019. Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective. Pharmacogenomics 20 (4) , pp. 279-290. 10.2217/pgs-2018-0188

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