Disease etiology and diagnosis by TCR repertoire analysis goes viral

Attaf, Meriem and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Disease etiology and diagnosis by TCR repertoire analysis goes viral. European Journal of Immunology 46 (11) , pp. 2516-2519. 10.1002/eji.201646649

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Abstract

The importance of T-cell receptor (TCR) repertoire diversity is highlighted in murine models of immunodeficiency and in many human pathologies. However, the true extent of TCR diversity and how this diversity varies in health and disease is poorly understood. In a previous issue of the European Journal of Immunology, Lossius et al. [Eur. J. Immunol. 2014. 44: 3439–3452] dissected the composition of the TCR repertoire in the context of multiple sclerosis (MS) using high-throughput sequencing of TCR-β chains in cerebrospinal fluid samples and blood. The authors demonstrated that the TCR repertoire of the CSF was largely distinct from the blood and enriched in EBV-reactive CD8+ T cells in MS patients. Studies of this kind have long been hindered by technical limitations and remain scarce in the literature. However, TCR sequencing methodologies are progressing apace and will undoubtedly shed light on the genetic basis of T-cell responses and the ontogeny of T-cell-mediated diseases, such as MS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Autoimmunity; High-throughput sequencing; TCR repertoire; Virus infection
Publisher:	John Wiley & Sons
ISSN:	0014-2980
Date of Acceptance:	10 October 2016
Last Modified:	21 Oct 2022 07:47
URI:	https://orca.cardiff.ac.uk/id/eprint/100745

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