A biased view toward celiac disease

Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Koning, F. 2016. A biased view toward celiac disease. Mucosal Immunology 9 (3) , pp. 583-586. 10.1038/mi.2016.17

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Abstract

Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Nature Publishing Group
ISSN:	1933-0219
Date of First Compliant Deposit:	10 July 2017
Date of Acceptance:	23 February 2016
Last Modified:	02 Nov 2022 11:30
URI:	https://orca.cardiff.ac.uk/id/eprint/102238

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