Myb via TGFβ is required for collagen type 1 production and skin integrity

Sampurno, Shienny, Cross, Ryan, Pearson, Helen ORCID: https://orcid.org/0000-0002-3284-0843, Kaur, Pritinder, Malaterre, Jordane and Ramsay, Robert G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33 (2) , pp. 102-112. 10.3109/08977194.2015.1016222

Full text not available from this repository.

Abstract

Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the architecture of the skin of avian myeloblastosis viral oncogene homolog (Myb) knock-out (KO) embryos and wound repair in Myb+/− mice revealing a need for Myb in the skin, attributed to fibroblast-dependent production of collagen type 1. Here, using targeted Myb deletion in keratin-14 (K14) positive cells we reveal further Myb-specific defects in epidermal cell proliferation, thickness and ultrastructural morphology. This was associated with a severe deficit in collagen type 1 production, reminiscent of that observed in patients with ichthyosis vulgaris and Ehlers–Danlos syndrome. Since collagen type 1 is a product of fibroblasts, the collagen defect observed was unexpected and appears to be directed by the loss of Myb with significantly reduced tumor growth factor beta 1 (Tgfβ−1) expression by primary keratinocytes. Our findings support a specific role for Myb in K14+ epithelial cells in the preservation of adult skin integrity and function.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Informa Healthcare
ISSN:	0897-7194
Date of Acceptance:	3 February 2015
Last Modified:	22 Jun 2023 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/103600

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item