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Number of items: 33.

Hodson, Kieran, Arredondo, Hector M., Humphrey, William E., Flanagan, Dustin J., Vincan, Elizabeth, Willert, Karl, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 and Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 2025. Targeting cancer with Paris' arrow: An updated perspective on targeting Wnt Receptor Frizzled 7. Sci 7 (2) , 61. 10.3390/sci7020061
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Al-janabi, Haider, Moyes, Katy, Allen, Richard, Fisher, Matthew, Crespo, Mateus, Gurel, Bora, Rescigno, Pasquale, de Bono, Johann, Nunns, Harry, Bailey, Christopher, Junker-Jensen, Anna, Muthana, Munitta, Phillips, Wayne A., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Taplin, Mary-Ellen, Brown, Janet E. and Lewis, Claire E. 2024. Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy. Journal for ImmunoTherapy of Cancer 12 (7) , e009368. 10.1136/jitc-2024-009368
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Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Mullen, Manisha S., Bullock, Nicholas P., Gilroy, Kathryn L., Richards, Anna E., Patel, Radhika, Quintela, Marcos, Meniel, Valerie S., Seaton, Gillian, Kynaston, Howard ORCID: https://orcid.org/0000-0003-1902-9930, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Nelson, Peter S., Haffner, Michael C., Staffurth, John N. ORCID: https://orcid.org/0000-0002-7834-3172 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2024. Development and characterisation of a new patient-derived Xenograft model of AR-negative metastatic asctration-resistant prostate cancer. Cells 13 (8) , 673. 10.3390/cells13080673
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Chessa, Tamara A.M., Jung, Piotr, Anwar, Arqum, Suire, Sabine, Anderson, Karen E., Barneda, David, Kielkowska, Anna, Sadiq, Barzan A., Lai, Ieng Wai, Felisbino, Sergio, Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Phillips, Wayne A., Sasaki, Junko, Sasaki, Takehiko, Oxley, David, Spensberger, Dominik, Segonds-Pichon, Anne, Wilson, Michael, Walker, Simon, Okkenhaug, Hanneke, Cosulich, Sabina, Hawkins, Phillip T. and Stephens, Len R. 2023. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular Cell 83 (16) , pp. 2991-3009. 10.1016/j.molcel.2023.07.015
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Owen, Jasmine S., Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2022. Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer. Biomolecules 13 (1) , 67. 10.3390/biom13010067
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Koushyar, Sarah, Meniel, Valerie S., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2022. Exploring the Wnt pathway as a therapeutic target for prostate cancer. Biomolecules 12 (2) , 309. 10.3390/biom12020309
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Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Bullock, Nicholas, Dass, Manisha S., Staffurth, John N. ORCID: https://orcid.org/0000-0002-7834-3172 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9 (11) , 2342. 10.3390/cells9112342
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Shorning, Boris Y., Dass, Manisha S., Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2020. The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling. International Journal of Molecular Sciences 21 (12) , 4507. 10.3390/ijms21124507
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Flanagan, Dustin J., Barker, Nick, Di Costanzo, Natasha S., Mason, Elizabeth A., Gurney, Austin, Meniel, Valerie S., Koushyar, Sarah, Austin, Chloe R., Ernst, Matthias, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2019. Frizzled-7 is required for Wnt signaling in gastric tumours with and without Apc mutations. Cancer Research 79 (5) , pp. 970-981. 10.1158/0008-5472.CAN-18-2095
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Li, Jason, Meniel, Valerie S., Fennell, Christina M., Waring, Paul, Montgomery, Karen G., Rebello, Richard J., Macpherson, Arthi A., Koushyar, Sarah, Furic, Luc, Cullinane, Carleen, Clarkson, Richard W. ORCID: https://orcid.org/0000-0001-7389-8673, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146, Simpson, Kaylene J., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Shepherd, Peter R., Humbert, Patrick O., Sansom, Owen J. and Phillips, Wayne A. 2018. Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery 8 (6) , pp. 764-779. 10.1158/2159-8290.CD-17-0867
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Martin, Ana Carolina B.M., Fuzer, Angelina M., Becceneri, Amanda B., da Silva, James Almada, Tomasin, Rebeka, Denoyer, Delphine, Kim, Soo-Hyun, McIntyre, Katherine A., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Yeo, Belinda, Nagpal, Aadya, Ling, Xiawei, Selistre-de-Araújo, Heloisa S., Vieira, Paulo Cézar, Cominetti, Marcia R. and Pouliot, Normand 2017. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget 8 (42) , pp. 72260-72271. 10.18632/oncotarget.20139
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Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A. and Clemons, Nicholas J. 2017. Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. Nature Communications 8 , 14844. 10.1038/ncomms14844
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Rebello, Richard J., Kusnadi, Eric, Cameron, Donald P., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Lesmana, Analia, Devlin, Jennifer R., Drygin, Denis, Clark, Ashlee K., Porter, Laura, Pedersen, John, Sandhu, Shahneen, Risbridger, Gail P., Pearson, Richard B. ORCID: https://orcid.org/0000-0002-3284-0843, Hannan, Ross D. and Furic, Luc 2016. The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer. Clinical Cancer Research 22 (22) , pp. 5539-5552. 10.1158/1078-0432.CCR-16-0124
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Denoyer, Delphine, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Clatworthy, Sharnel A.S., Smith, Zoe M., Francis, Paul S., Llanos, Roxana M., Volitakis, Irene, Phillips, Wayne A., Meggyesy, Peter M., Masaldan, Shashank and Cater, Michael A. 2016. Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution. Oncotarget 7 (24) , pp. 37064-37080. 10.18632/oncotarget.9245
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Wölwer, Christina B., Pase, Luke B., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Gödde, Nathan J., Lackovic, Kurt, Huang, David C. S., Russell, Sarah M. and Humbert, Patrick O. 2015. A chemical screening approach to identify novel key mediators of erythroid enucleation. PLoS ONE 10 (11) , e0142655. 10.1371/journal.pone.0142655
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, McGlinn, Edwina, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Schlüter, Holger, Srikumar, Anuratha, Gödde, Nathan J., Woelwer, Christina B., Ryan, Andrew, Phillips, Wayne A., Ernst, Matthias, Kaur, Pritinder and Humbert, Patrick 2015. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Molecular Cancer 14 , 169. 10.1186/s12943-015-0440-z
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Sampurno, Shienny, Cross, Ryan, Pearson, Helen ORCID: https://orcid.org/0000-0002-3284-0843, Kaur, Pritinder, Malaterre, Jordane and Ramsay, Robert G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33 (2) , pp. 102-112. 10.3109/08977194.2015.1016222

Johnstone, C. N., Smith, Y. E., Cao, Y., Burrows, A. D., Cross, R. S. N., Ling, X., Redvers, R. P., Doherty, J. P., Eckhardt, B. L., Natoli, A. L., Restall, C. M., Lucas, E., Pearson, H. B. ORCID: https://orcid.org/0000-0002-3284-0843, Deb, S., Britt, K. L., Rizzitelli, A., Li, J., Harmey, J. H., Pouliot, N. and Anderson, R. L. 2015. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. Disease Models and Mechanisms 8 (3) , pp. 237-251. 10.1242/dmm.017830
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Takizawa, Itsuhiro, Lawrence, Mitchell G., Balanathan, Preetika, Rebello, Richard, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Garg, Elika, Pedersen, John, Pouliot, Normand, Nadon, Robert, Watt, Matthew J., Taylor, Renea A., Humbert, Patrick, Topisirovic, Ivan, Larsson, Ola, Risbridger, Gail P. and Furic, Luc 2015. Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity. Oncotarget 6 (2) , pp. 604-616. 10.18632/oncotarget.2820
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Elsum, I. A., Yates, L. L., Pearson, H. B. ORCID: https://orcid.org/0000-0002-3284-0843, Phesse, T. J. ORCID: https://orcid.org/0000-0001-9568-4916, Long, F., O'Donoghue, R., Ernst, M., Cullinane, C. and Humbert, P. O. 2014. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene 33 (48) , pp. 5523-5533. 10.1038/onc.2013.498

Gödde, Nathan J, Pearson, Helen B ORCID: https://orcid.org/0000-0002-3284-0843, Smith, Lorey K and Humbert, Patrick O 2014. Dissecting the role of polarity regulators in cancer through the use of mouse models. Experimental Cell Research 328 (2) , pp. 249-257. 10.1016/j.yexcr.2014.08.036

DiTommaso, Tia, Cottle, Denny L., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Schlüter, Holger, Kaur, Pritinder, Humbert, Patrick O. and Smyth, Ian M. 2014. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genetics 10 (10) , e1004706. 10.1371/journal.pgen.1004706
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Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Buchert, Michael, Stuart, Emma, Flanagan, Dustin J., Faux, Maree, Afshar-Sterle, Shoukat, Walker, Francesca, Zhang, Hui-Hua, Nowell, Cameron J., Jorissen, Robert, Tan, Chin Wee, Hirokawa, Yumiko, Eissmann, Moritz F., Poh, Ashleigh R., Malaterre, Jordane, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Kirsch, David G., Provero, Paolo, Poli, Valeria, Ramsay, Robert G., Sieber, Oliver, Burgess, Antony W., Huszar, Dennis, Vincan, Elizabeth and Ernst, Matthias 2014. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration. Science Signaling 7 (345) , ra92. 10.1126/scisignal.2005411

Phesse, T. J. ORCID: https://orcid.org/0000-0001-9568-4916, Myant, K. B., Cole, A. M., Ridgway, R. A., Pearson, H. ORCID: https://orcid.org/0000-0002-3284-0843, Muncan, V., van den Brink, G. R., Vousden, K. H., Sears, R., Vassilev, L . T ., Clarke, A. R. ORCID: https://orcid.org/0000-0002-4281-426X and Sansom, O. J. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 21 (6) , pp. 956-966. 10.1038/cdd.2014.15
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Godde, Nathan J., Sheridan, Julie M., Smith, Lorey K., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Britt, Kara L., Galea, Ryan C., Yates, Laura L., Visvader, Jane E. and Humbert, Patrick O. 2014. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genetics 10 (5) , e1004323. 10.1371/journal.pgen.1004323
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Cater, Michael A., Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal 2013. Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology 8 (7) , pp. 1621-1631. 10.1021/cb400198p

Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2013. Modelling metastasis in vivo. Madame Curie Bioscience Database, Georgetown TX: Landes Bioscience,

Pouliot, Normand, Pearson, Helen ORCID: https://orcid.org/0000-0002-3284-0843 and Burrows, Allan 2013. Investigating metastasis using in vitro platforms. Madame Curie Bioscience Database, Georgetown TX: Landes Bioscience,

Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Perez-Mancera, Pedro A., Dow, Lukas E., Ryan, Andrew, Tennstedt, Pierre, Bogani, Debora, Elsum, Imogen, Greenfield, Andy, Tuveson, David A., Simon, Ronald and Humbert, Patrick O. 2011. SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. The Journal of Clinical Investigation 121 (11) , pp. 4257-4267. 10.1172/JCI58509
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Shorning, Boris, Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, McCarthy, Afshan, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Winton, Douglas J., Sansom, Owen J., Ashworth, Alam and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4 (1) , e4264. 10.1371/journal.pone.0004264
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Research 69 (1) , pp. 94-101. 10.1158/0008-5472.CAN-08-2895

Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, McCarthy, A., Collins, C. M., Ashworth, A. and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2008. Lkb1 defiency causes prostate neoplasia in the mouse. Cancer Research 68 (7) , pp. 2223-2232. 10.1158/0008-5472.CAN-07-5169

Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2008. Development and characterisation of novel mouse models of human prostate cancer. PhD Thesis, Cardiff University.
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This list was generated on Wed Oct 29 23:32:34 2025 GMT.


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