Li, H., Ye, C., Ji, G., Wu, X., Xiang, Z., Li, Y., Cao, Y., Liu, X., Douek, D. C., Price, D. A.  ORCID: https://orcid.org/0000-0001-9416-2737 and Han, J.
2012.
Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.
Journal of Immunology
189
(5)
, pp. 2404-2413.
10.4049/jimmunol.1102087
|
Abstract
Overlap of TCR repertoires among individuals provides the molecular basis for public T cell responses. By deep-sequencing the TCRβ repertoires of CD4+CD8+ thymocytes from three individual mice, we observed that a substantial degree of TCRβ overlap, comprising ∼10–15% of all unique amino acid sequences and ∼5–10% of all unique nucleotide sequences across any two individuals, is already present at this early stage of T cell development. The majority of TCRβ sharing between individual thymocyte repertoires could be attributed to the process of convergent recombination, with additional contributions likely arising from recombinatorial biases; the role of selection during intrathymic development was negligible. These results indicate that the process of TCR gene recombination is the major determinant of clonotype sharing between individuals.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| Date of First Compliant Deposit: | 18 September 2017 |
| Date of Acceptance: | 23 June 2012 |
| Last Modified: | 03 Nov 2022 09:24 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/104746 |
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