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An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients

Wainwright, Shane Daniel, Bondeson, Jan and Hughes, Clare Elizabeth ORCID: 2006. An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients. Matrix Biology 25 (5) , pp. 317-320. 10.1016/j.matbio.2006.03.006

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The major proteoglycan of articular cartilage aggrecan is a substrate for ADAMTS4. RT-PCR analysis of human osteoarthritic (OA) synovial co-cultures using oligonucleotide primers designed to amplify across the exon 8/9 junction of human ADAMTS4 resulted in the amplification of two products, the expected product and a smaller product missing 161 bp from the 5′ end of exon 9, the result of alternative splicing in which exon 8 joins to a cryptic 3′ splice site within exon 9. The protein produced would be identical to human ADAMTS4 up to Arg696, and would have a new C-terminal domain with no commonality with the ADAMTS4 spacer domain. Changes in the C-terminal domain of ADAMTS4 may alter its substrate specificity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords: ADAMTS4; Synovium; Alternative splice; Osteoarthritis
Publisher: Elsevier
ISSN: 0945-053X
Last Modified: 01 Dec 2022 10:01

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