High spatio-temporal resolution in functional MRI with 3D echo planar imaging using cylindrical excitation and a CAIPIRINHA undersampling pattern

van der Zwaag, Wietske, Reynaud, Oliviee, Narsude, Mayur, Gallichan, Daniel ORCID: https://orcid.org/0000-0002-0143-2855 and Marques, José P. 2018. High spatio-temporal resolution in functional MRI with 3D echo planar imaging using cylindrical excitation and a CAIPIRINHA undersampling pattern. Magnetic Resonance in Medicine 79 (5) , pp. 2589-2596. 10.1002/mrm.26906

Preview

PDF - Accepted Post-Print Version Download (568kB) | Preview

Abstract

Purpose The combination of 3D echo planar imaging (3D‐EPI) with a 2D‐CAIPIRINHA undersampling scheme provides high flexibility in the optimization for spatial or temporal resolution. This flexibility can be increased further with the addition of a cylindrical excitation pulse, which exclusively excites the brain regions of interest. Here, 3D‐EPI was combined with a 2D radiofrequency pulse to reduce the brain area from which signal is generated, and hence, allowing either reduction of the field of view or reduction of parallel imaging noise amplification. Methods 3D‐EPI with cylindrical excitation and 4 × 3‐fold undersampling in a 2D‐CAIPIRINHA sampling scheme was used to generate functional MRI (fMRI) data with either 2‐mm or 0.9‐mm in‐plane resolution and 1.1‐s temporal resolution over a 5‐cm diameter cylinder placed over both temporal lobes for an auditory fMRI experiment. Results Significant increases in image signal‐to‐noise ratio (SNR) and temporal SNR (tSNR) were found for both 2‐mm isotropic data and the high‐resolution protocol when using the cylindrical excitation pulse. Both protocols yielded highly significant blood oxygenation level–dependent responses for the presentation of natural sounds. Conclusion The higher tSNR of the cylindrical excitation 3D‐EPI data makes this sequence an ideal choice for high spatiotemporal resolution fMRI acquisitions. Magn Reson Med 79:2589–2596, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Engineering
Publisher:	Wiley
ISSN:	0740-3194
Date of First Compliant Deposit:	21 September 2017
Date of Acceptance:	17 August 2017
Last Modified:	20 Nov 2024 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/104932

Citation Data

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item