Hu, Changyun, Deng, Songyan, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2008. Anti-CD20 treatment prolongs syngeneic Islet graft survival and delays the onset of recurrent autoimmune diabetes. Annals of the New York Academy of Sciences 1150 (1) , pp. 217-219. 10.1196/annals.1447.032 |
Abstract
Type 1 diabetes is an autoimmune disease characterized by T cell–mediated destruction of pancreatic islet beta cells. Pancreatic islet transplantation with long-term immunosuppressive drug treatment is an accepted therapeutic option for patients with type 1 diabetes suffering from disabling hypoglycemia on insulin treatment. Here we investigated the replacement of immunosuppressive drug treatment with immune tolerance establishment induced by temporary B cell–depletion therapy for islet transplantation. The result suggested that the combined therapy of B cell depletion and syngeneic islet transplantation may reverse the disease in hCD20/NOD mice.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Wiley-Blackwell |
ISSN: | 0077-8923 |
Last Modified: | 03 Nov 2022 09:33 |
URI: | https://orca.cardiff.ac.uk/id/eprint/105282 |
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