Developing a novel model system to target insulin-reactive CD8 T cells

Scott, Gwen S., Fishman, Sigal, Margalit, Alon, Siew, L. Khai, Chapman, Stephen, Wen, Li, Gross, Gideon and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2008. Developing a novel model system to target insulin-reactive CD8 T cells. Annals of the New York Academy of Sciences 1150 (1) , pp. 54-58. 10.1196/annals.1447.040

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Abstract

CD8 T cells play an important role in autoimmune diabetes development, and therefore removing these cells may protect against disease. To test this, we designed a novel method using engineered cells (InsCD3-ζ) to target insulin-specific CD8 T cells. Insulin-reactive target cells were cultured with InsCD3-ζ CD8 T cells and cytotoxicity was assessed. Activated, but not naïve, InsCD3-ζ CD8 T cells readily killed insulin-reactive target CD8 T cells. This approach to immunotarget relevant pathogenic CD8 T cells may be a therapeutic option to delay or prevent type 1 diabetes.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0077-8923
Last Modified:	03 Nov 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/105286

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