Newland, Benjamin ORCID: https://orcid.org/0000-0002-5214-2604, Baeger, Marcel, Eigel, Dimitri, Newland, Heike and Werner, Carsten 2017. Oxygen-producing gellan gum hydrogels for dual delivery of either oxygen or peroxide with doxorubicin. ACS Biomaterials Science & Engineering 3 (5) , pp. 787-792. 10.1021/acsbiomaterials.7b00078 |
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Abstract
Hypoxic environments in the core of tumors can give rise to resistance against anticancer therapeutics. Oxygen-producing biomaterials may be able to improve chemotherapeutic efficiency by locally disrupting the hypoxic environment. We hypothesized that gellan gum hydrogels could be loaded with both a solid peroxide and the chemotherapeutic drug doxorubicin, to release both oxygen and doxorubicin simultaneously. We show that calcium peroxide physically cross-links gellan gum into a hydrogel, which when loaded with catalase raises the dissolved oxygen content of media for up to 64 h. Additionally, doxorubicin could be loaded into the hydrogel in situ, allowing release in well-defined quantities.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences Pharmacy |
Publisher: | ACS Publications |
ISSN: | 2373-9878 |
Date of First Compliant Deposit: | 31 October 2017 |
Date of Acceptance: | 10 April 2017 |
Last Modified: | 06 Nov 2023 23:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/106096 |
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