Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?

Powell, Alison, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Hughes, Clare ORCID: https://orcid.org/0000-0003-4726-5877, Paul, Alison ORCID: https://orcid.org/0000-0002-7653-9964, James, Craig ORCID: https://orcid.org/0000-0002-0569-182X, Hopkins, Stephen, Mansour, Omar and Griffiths, Peter 2017. Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route? Journal of Drug Targeting 25 (9-10) , pp. 919-926. 10.1080/1061186X.2017.1378660

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Abstract

The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through a cartilaginous extracellular matrix into chondrocytes, with little perturbation of the matrix structure, indicating that targeting of potential therapeutics through a cartilaginous extracellular matrix should be proven possible. Rapid chondrocytic targeting of drugs which require intra cellularisation for their activity and uniform extracellular concentrations of drugs with an extracellular target, is thus enabled though polymer conjugation.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences Chemistry
Publisher:	Informa Healthcare
ISSN:	1061-186X
Funders:	Engineering and Physical Sciences Research Council
Date of First Compliant Deposit:	6 November 2017
Date of Acceptance:	8 September 2017
Last Modified:	06 May 2023 20:40
URI:	https://orca.cardiff.ac.uk/id/eprint/106243

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