Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Furby, Hannah ORCID: https://orcid.org/0000-0002-7279-1812, Breen, Rachel, Brookes-Howell, Lucy ORCID: https://orcid.org/0000-0002-8263-7130, Cheney, Drew, Playle, Rebecca ORCID: https://orcid.org/0000-0002-2989-1092, Watson, Gareth, Metzler-Baddeley, Claudia ORCID: https://orcid.org/0000-0002-8646-1144, Rosser, Anne ORCID: https://orcid.org/0000-0002-4716-4753 and Busse-Morris, Monica ORCID: https://orcid.org/0000-0002-5331-5909 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4 , 45. 10.1186/s40814-018-0237-0

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Abstract

Background Cognitive impairments, especially deficits of executive function, have been well documented as a core and early feature in Huntington’s disease (HD). Cognitive impairments represent considerable burden and can be devastating for people and families affected by HD. Computerised cognitive training interventions that focus on improving executive function present a possible non-pharmacological treatment option. We propose to determine the feasibility, acceptability, and appropriate outcome measures for use in a randomised controlled feasibility study. Methods/design Participants will be randomised into either a computerised cognitive training group or a control group. Those randomised to the training group will be asked to complete a cognitive training intervention based on the HappyNeuron Pro software tasks of executive function, for a minimum of 30 min, three times a week for the 12-week study duration. Participants in the control group will not receive computerised cognitive training but will receive a similar degree of social interaction via equivalent study and home visits. We will explore quantitative outcome measures, including measures of cognitive performance, motor function, questionnaires and semi-structured interviews, as well as magnetic resonance imaging (MRI) measures in a subset of participants. Feasibility will be determined through assessment of recruitment, retention, adherence and acceptability of the intervention. Discussion The results of this study will provide crucial guidance and information regarding the feasibility of conducting a randomised controlled study into computerised cognitive training in HD. This study is crucial for the development of larger definitive randomised controlled trials which are powered to determine efficacy and for the development of future cognitive training programmes for people affected by HD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Psychology
Publisher:	BioMed Central
ISSN:	2055-5784
Date of First Compliant Deposit:	20 March 2018
Date of Acceptance:	18 January 2018
Last Modified:	14 May 2023 18:30
URI:	https://orca.cardiff.ac.uk/id/eprint/108209

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