An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation

Moore, Thomas O., Paradowski, Michael and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2016. An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation. Organic and Biomolecular Chemistry 14 (12) , pp. 3307-3313. 10.1039/C6OB00340K

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Abstract

A novel approach of the convergent functionalisation of aryl dibromides to form NS5A type inhibitors using C–H activation is reported. The focus of investigation was to reduce the formation of homodimeric side product, as well as to investigate the scope of different aryl dibromides that were tolerated under the reaction conditions. The C–H activation methodology was found to give a viable synthetic route to NS5A inhibitors, with late stage functionalisation of the core portion of the molecule, albeit with some chemical functionalities not tolerated.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences Medicine
Publisher:	Royal Society of Chemistry
ISSN:	1477-0520
Date of First Compliant Deposit:	22 February 2018
Date of Acceptance:	25 February 2016
Last Modified:	08 Feb 2024 02:05
URI:	https://orca.cardiff.ac.uk/id/eprint/109275

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