Discovery of the first potent, selective 5-Hydroxytryptamine1D receptor antagonist [Letter]

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harrington, Frank P., Gordon, Laurie J., Hopley, Susanna C., Scott, Claire M. and Watson, Jeannette M. 2005. Discovery of the first potent, selective 5-Hydroxytryptamine1D receptor antagonist [Letter]. Journal of Medicinal Chemistry 48 (10) , pp. 3478-3480. 10.1021/jm049039v

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Abstract

A series of 5-(piperidinylethyloxy)quinoline 5-hydroxytryptamine1D (5-HT1D) receptor antagonists have been discovered from elaboration of the series of dual 5-hydroxytryptamine1−selective serotonin reuptake inhibitors (5HT1−SSRIs) reported previously. This is the first report of highly potent, selective antagonists for the 5-HT1D receptor, which represents an extremely useful set of pharmacological tools for further understanding the roles of the 5-HT1 receptor subtypes.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	American Chemical Society
ISSN:	0022-2623
Last Modified:	23 Oct 2022 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/109407

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