A novel synthesis of tert-leucine via a Leuckart type reaction

Adger, Brian M., Dyer, Ulrich C., Lennon, Ian C., Tiffin, Peter D. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 1998. A novel synthesis of tert-leucine via a Leuckart type reaction. Tetrahedron Letters 38 (12) , pp. 2153-2154. 10.1016/S0040-4039(97)00269-4

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Abstract

An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-methylbenzylamine allows entry into either (R)-or (S)-tert-leucine.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0040-4039
Date of Acceptance:	7 February 1997
Last Modified:	23 Oct 2022 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/109421

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