Calcineurin knockout mice show a selective loss of small spines

Okazaki, Hitoshi, Hayashi-Takagi, Akiko, Nagaoka, Akira, Negishi, Makiko, Ucar, Hasan, Yagishita, Sho, Ishii, Kazuhiko, Toyoizumi, Taro, Fox, Kevin ORCID: https://orcid.org/0000-0002-2563-112X and Kasai, Haruo 2018. Calcineurin knockout mice show a selective loss of small spines. Neuroscience Letters 671 , pp. 99-102. 10.1016/j.neulet.2018.02.006

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Abstract

Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Elsevier
ISSN:	0304-3940
Date of First Compliant Deposit:	12 March 2018
Date of Acceptance:	3 February 2018
Last Modified:	08 May 2023 20:44
URI:	https://orca.cardiff.ac.uk/id/eprint/109808

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