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Calcineurin knockout mice show a selective loss of small spines

Okazaki, Hitoshi, Hayashi-Takagi, Akiko, Nagaoka, Akira, Negishi, Makiko, Ucar, Hasan, Yagishita, Sho, Ishii, Kazuhiko, Toyoizumi, Taro, Fox, Kevin ORCID: and Kasai, Haruo 2018. Calcineurin knockout mice show a selective loss of small spines. Neuroscience Letters 671 , pp. 99-102. 10.1016/j.neulet.2018.02.006

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Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0304-3940
Date of First Compliant Deposit: 12 March 2018
Date of Acceptance: 3 February 2018
Last Modified: 08 May 2023 20:44

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