Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel

Williams, Sandile Elroy Johnathan, Wootton, Phillippa, Mason, Helen Sarah, Bould, Jonathan, Iles, David E., Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163, Peers, Chris and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science , pp. 2993-2997. 10.1126/science.1105010

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Abstract

Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia. Knockdown of HO-2 expression reduced channel activity, and carbon monoxide, a product of HO-2 activity, rescued this loss of function. Inhibition of BK channels by hypoxia was dependent on HO-2 expression and was augmented by HO-2 stimulation. Furthermore, carotid body cells demonstrated HO-2–dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology
ISSN:	0036-8075
Last Modified:	17 Oct 2022 08:48
URI:	https://orca.cardiff.ac.uk/id/eprint/1114

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