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Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars

Luukkonen, Panu K., Sädevirta, Sanja, Zhou, You ORCID:, Kayser, Brandon, Ali, Ashfaq, Ahonen, Linda, Lallukka, Susanna, Pelloux, Veronique, Gaggini, Melania, Jian, Ching, Hakkarainen, Antti, Lundbom, Nina, Gylling, Helena, Salonen, Anne, Oresic, Matej, Hyotylainen, Tuulia, Orho-Melander, Marju, Rissanen, Aila, Gastaldelli, Amalia, Clement, Karine, Hodson, Leanne and Yki-Jarvinen, Hannele 2018. Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars. Diabetes Care 41 (8) , pp. 1732-1739. 10.2337/dc18-0071

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OBJECTIVE Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG. RESEARCH DESIGN AND METHODS We overfed 38 overweight subjects (age 48 ± 2, BMI 31 ± 1 kg/m2, liver fat 4.7 ± 0.9%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (1H-MRS), pathways contributing to IHTG (lipolysis ([2H5]glycerol) and DNL (2H2O) basally and during euglycemic hyperinsulinemia, insulin resistance, endotoxemia, plasma ceramides, and adipose tissue gene expression at 0 and 3 weeks. RESULTS Overfeeding SAT increased IHTG more (+55%) than UNSAT (+15%, P < 0.05). CARB increased IHTG (+33%) by stimulating DNL (+98%). SAT significantly increased while UNSAT decreased lipolysis. SAT induced insulin resistance and endotoxemia and significantly increased multiple plasma ceramides. The diets had distinct effects on adipose tissue gene expression. CONCLUSIONS Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Publisher: American Diabetes Association
ISSN: 0149-5992
Date of First Compliant Deposit: 5 June 2018
Date of Acceptance: 1 May 2018
Last Modified: 11 Nov 2023 03:24

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