Browse by Current Cardiff authors

Wang, Hongyu, Bai, Ran, Wang, Yubing, Qu, Meihua, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Gao, Zhiqin and Wang, Yi 2025. The multifaceted function of FoxO1 in pancreatic β-cell dysfunction and insulin resistance: Therapeutic potential for type 2 diabetes. Life Sciences 364 , 123384. 10.1016/j.lfs.2025.123384 Item availability restricted.

Nagaraj, Meghana, Emmagouni, Sharath Kumar Goud, Chaurasiya, Vaishali, Li, Luyang, Nguyen, Van Dien, Keskitalo, Salla, Varjosalo, Markku, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Haridas, P. A. Nidhina and Olkkonen, Vesa M. 2025. Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis. FEBS Letters 10.1002/1873-3468.70001 Item availability restricted.

Zhou, Limin, Liu, Jiejie, Yao, Peipei, Liu, Xing, Chen, Fei, Chen, Yu, Zhou, Li, Shen, Chao, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Du, Xin and Hu, Junbo 2024. Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma. Journal of Translational Medicine 22 (1) , 1163. 10.1186/s12967-024-06011-y

Lluch, Aina, Latorre, Jèssica, Oliveras-Cañellas, Núria, Fernández-Sánchez, Ana, Moreno-Navarrete, José M., Castells-Nobau, Anna, Comas, Ferran, Buxò, Maria, Rodríguez-Hermosa, José I., Ballester, María, Espadas, Isabel, Martin-Montalvo, Alejandro, Zhang, Birong, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Burkhardt, Ralph, Höring, Marcus, Liebisch, Gerhard, Castellanos-Rubio, Ainara, Santin, Izortze, Kar, Asha, Laakso, Markku, Pajukanta, Päivi, Olkkonen, Vesa M., Fernández-Real, José M. and Ortega, Francisco J. 2024. A novel long non-coding RNA connects obesity to impaired adipocyte function. Molecular Metabolism 90 , 102040. 10.1016/j.molmet.2024.102040

Paget, James T., Ward, Joseph A., McKean, Andrew R., Mansfield, David C., McLaughlin, Martin, Kyula-Currie, Joan N., Smith, Henry G., Roulstone, Victoria, Li, Chunhei, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hardiman, Thomas, Grigoriadis, Anita, O'Brien Coon, Devin, Irshad, Sheeba, Melcher, Alan A., Harrington, Kevin J. and Khan, Aadil 2024. CXCL12-targeted immunomodulatory gene therapy reduces radiation-induced fibrosis in healthy tissues. Molecular Cancer Therapeutics 10.1158/1535-7163.MCT-23-0872 Item availability restricted.

Hu, Bangli, Yin, Yixin, Zhang, Birong, Li, Siqi, Li, Kezhi, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Huang, Qinghua 2024. Villin-1 regulates ferroptosis in colorectal cancer progression. The FEBS Journal 10.1111/febs.17350 Item availability restricted.

Zhang, Xiaoyan, Dumčius, Povilas, Mikhaylov, Roman, Qi, Jiangfa, Stringer, Mercedes, Sun, Chao, Nguyen, Van Dien, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sun, Xianfang ORCID: https://orcid.org/0000-0002-6114-0766, Liang, Dongfang, Liu, Dongge, Yan, Bing, Feng, Xi, Mei, Changjun, Xu, Cong, Feng, Mingqian, Fu, Yongqing, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Zhi, Ruicong, Tian, Liangfei, Dong, Zhiqiang and Yang, Xin ORCID: https://orcid.org/0000-0002-8429-7598 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11 (39) , 2403574. 10.1002/advs.202403574

Nguyen, Van Dien, Hughes, Timothy R. ORCID: https://orcid.org/0000-0003-2348-3490 and Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 2024. From complement to complosome in non‐alcoholic fatty liver disease: when location matters. Liver International 44 (2) , pp. 316-329. 10.1111/liv.15796

Li, Shiqian, Wang, Yafei, van der Stoel, Miesje, Zhou, Xin, Madhusudan, Shrinidhi, Kanerva, Kristiina, Nguyen, Van Dien, Eskici, Nazli, Olkkonen, Vesa M., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Raivio, Taneli and Ikonen, Elina 2024. HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells. Genome Biology 25 , 58. 10.1186/s13059-024-03187-w

Chaurasiya, Vaishali, Pham, Dan Duc, Harju, Jukka, Juuti, Anne, Penttilä, Anne, Emmagouni, Sharath Kumar Goud, Nguyen, Van Dien, Zhang, Birong, Perttunen, Sanni, Keskitalo, Salla, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Pietiläinen, Kirsi H., Haridas, P.A. Nidhina and Olkkonen, Vesa M. 2023. Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication. Experimental Cell Research 433 (2) , 113819. 10.1016/j.yexcr.2023.113819

Wright, Oliver, Harris, Anna, Nguyen, Van Dien, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Durand, Maxim, Jayyaratnam, Abbie, Gormley, Darren, O?Neill, Luke A. J., Triantafilou, Kathy, Nichols, Eva Maria and Booty, Lee M. 2023. C5aR2 regulates STING-mediated interferon beta production in human macrophages. Cells 12 (23) , 2707. 10.3390/cells12232707

Lin, Huiqing, Liu, Jiejie, Li, Ning, Zhang, Birong, Nguyen, Van Dien, Yao, Peipei, Feng, Jiangpeng, Liu, Qianyun, Chen, Yu, Li, Guang, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Zhou, Li 2023. NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19. Clinical Immunology 254 , 109687. 10.1016/j.clim.2023.109687

Chen, Yu, Liu, Qianyun, Zhou, Li, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Yan, Huan and Lan, Ke 2023. Emerging SARS-CoV-2 variants: Why, how, and what's next? Cell Insight 1 (3) , 100029. 10.1016/j.cellin.2022.100029

Graham, Rosalind, Gazinska, Patrycja, Zhang, Birong, Khiabany, Atousa, Sinha, Shubhankar, Alaguthurai, Thanussuyah, Flores-Borja, Fabian, Vicencio, Jose, Beuron, Fabienne, Roxanis, Ioannis, Matkowski, Rafal, Liam-Or, Revadee, Tutt, Andrew, Ng, Tony, Al-Jamal, Khuloud T., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Irshad, Sheeba 2023. Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes. Frontiers in Immunology 14 , 1204224. 10.3389/fimmu.2023.1204224

Robb, Calum T., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Felton, Jennifer M., Zhang, Birong, Goepp, Marie, Jheeta, Privjyot, Smyth, Danielle J., Duffin, Rodger, Vermeren, Sonja, Breyer, Richard M., Narumiya, Shuh, McSorley, Henry J., Maizels, Rick M., Schwarze, Jürgen K. J., Rossi, Adriano G. and Yao, Chengcan 2023. Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses. Allergy 78 (3) , pp. 714-730. 10.1111/all.15541

Wang, Hanlin, Yuan, Fan, Xie, Zhihua ORCID: https://orcid.org/0000-0002-5180-8427, Sun, Chao, Wu, Fangda, Mikhaylov, Roman, Shen, Minghong, Yang, Jian ORCID: https://orcid.org/0000-0003-2631-4553, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liang, Dongfang, Sun, Xianfang ORCID: https://orcid.org/0000-0002-6114-0766, Wu, Zhenlin, Yang, Zhiyong and Yang, Xin ORCID: https://orcid.org/0000-0002-8429-7598 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205 , 109258. 10.1016/j.apacoust.2023.109258

Asghar, Muhammad Yasir, Knuutinen, Taru, Holm, Emilia, Nordström, Tommy, Nguyen, Van Dien, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Törnquist, Kid 2022. Suppression of calcium entry modulates the expression of TRβ1 and Runx2 in thyroid cancer cells, two transcription factors that regulate invasion, proliferation and thyroid-specific protein levels. Cancers 14 (23) , 5838. 10.3390/cancers14235838

Sun, Chao, Dong, Yinhua, Wei, Jun, Cai, Meng, Liang, Dongfang, Fu, Yongqing, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sui, Yi, Wu, Fangda, Mikhaylov, Roman, Wang, Hanlin, Fan, Feifei, Xie, Zhihua ORCID: https://orcid.org/0000-0002-5180-8427, Stringer, Mercedes, Yang, Zhiyong ORCID: https://orcid.org/0000-0002-8429-7598, Wu, Zhenlin, Tian, Liangfei and Yang, Xin ORCID: https://orcid.org/0000-0002-8429-7598 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151 , pp. 333-345. 10.1016/j.actbio.2022.07.041

Nagaraj, Meghana, Höring, Marcus, Ahonen, Maria A., Nguyen, Van Dien, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Vihinen, Helena, Jokitalo, Eija, Liebisch, Gerhard, Nidhina Haridas, P.A. and Olkkonen, Vesa M. 2022. GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth. Journal of Lipid Research 63 (9) , 100259. 10.1016/j.jlr.2022.100259

Lluch, Aina, Veiga, Sonia R., Latorre, Jèssica, Moreno-Navarrete, José M., Bonifaci, Núria, Dien Nguyen, Van, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Höring, Marcus, Liebisch, Gerhard, Olkkonen, Vesa M., Llobet-Navas, David, Thomas, George, Rodríguez-Barrueco, Ruth, Fernández-Real, José M., Kozma, Sara C. and Ortega, Francisco J. 2022. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis. JCI Insight 7 (14) , e150461. 10.1172/jci.insight.150461

Ahonen, Maria A., Höring, Marcus, Nguyen, Van Dien, Qadri, Sami, Taskinen, Juuso H., Nagaraj, Meghana, Wabitsch, Martin, Fischer-Posovszky, Pamela, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liebisch, Gerhard, Haridas, P. A. Nidhina, Yki-Järvinen, Hannele and Olkkonen, Vesa M. 2022. Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. Molecular Medicine 28 (1) , 68. 10.1186/s10020-022-00496-3

Takala, Rabaa, Ramji, Dipak ORCID: https://orcid.org/0000-0002-6419-5578, Andrews, Robert, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Farhat, Mustafa, Elmajee, Mohammed, Rundle, Shelley and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2022. Pinolenic acid exhibits Anti-inflammatory and Anti-atherogenic effects in Peripheral blood- derived Monocytes from patients with Rheumatoid Arthritis. Scientific Reports 12 , 8807. 10.1038/s41598-022-12763-8

Arora, Amita, Kivelä, Annukka M., Wang, Ling, Minkeviciene, Rimante, Taskinen, Juuso H., Zhang, Birong, Koponen, Annika, Sun, Jing, Shirane, Michiko, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hotulainen, Pirta, Raiborg, Camilla and Olkkonen, Vesa M. 2022. Protrudin regulates FAK activation, endothelial cell migration and angiogenesis. Cellular and Molecular Life Sciences 79 (4) , 220. 10.1007/s00018-022-04251-z

Takala, Rabaa, Ramji, Dipak P ORCID: https://orcid.org/0000-0002-6419-5578, Andrews, Robert, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Burston, James and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2022. Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis. Rheumatology 61 (3) , pp. 992-1004. 10.1093/rheumatology/keab467

Goepp, Marie, Crittenden, Siobhan, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Rossi, Adriano G, Narumiya, Shuh and Yao, Chengcan 2021. Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling. Immunology 164 (4) , pp. 777-791. 10.1111/imm.13417

Asghar, Muhammad Yasir, Lassila, Taru, Paatero, Ilkka, Nguyen, Van Dien, Kronqvist, Pauliina, Zhang, Jixi, Silta, Anna, Löf, Christoffer, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Rosenholm, Jessica and Törnquist, Kid 2021. Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells. Cellular and Molecular Life Sciences 78 , pp. 5827-5846. 10.1007/s00018-021-03880-0

Crittenden, Siobhan, Goepp, Marie, Pollock, Jolinda, Robb, Calum T., Smyth, Danielle J., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Andrews, Robert, Tyrrell, Victoria, Gkikas, Konstantinos, Adima, Alexander, O'Connor, Richard A., Davies, Luke, Li, Xue-Feng, Yao, Hatti X., Ho, Gwo-Tzer, Zheng, Xiaozhong, Mair, Amil, Vermeren, Sonja, Qian, Bin-Zhi, Mole, Damian J., Gerasimidis, Konstantinos, Schwarze, Jürgen K. J., Breyer, Richard M., Arends, Mark J., O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Iredale, John P., Anderton, Stephen M., Narumiya, Shuh, Maizels, Rick M., Rossi, Adriano G., Howie, Sarah E. and Yao, Chengcan 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7 (7) , eabd7954. 10.1126/sciadv.abd7954

Abdul-Jawad, Sultan, Baù, Luca, Alaguthurai, Thanussuyah, del Molino del Barrio, Irene, Laing, Adam G., Hayday, Thomas S., Monin, Leticia, Muñoz-Ruiz, Miguel, McDonald, Louisa, Francos Quijorna, Isaac, McKenzie, Duncan, Davis, Richard, Lorenc, Anna, Chan, Julie Nuo En, Ryan, Sarah, Bugallo-Blanco, Eva, Yorke, Rozalyn, Kamdar, Shraddha, Fish, Matthew, Zlatareva, Iva, Vantourout, Pierre, Jennings, Aislinn, Gee, Sarah, Doores, Katie, Bailey, Katharine, Hazell, Sophie, De Naurois, Julien, Moss, Charlotte, Russell, Beth, Khan, Aadil A., Rowley, Mark, Benjamin, Reuben, Enting, Deborah, Alrifai, Doraid, Wu, Yin, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Barber, Paul, Ng, Tony, Spicer, James, Van Hemelrijck, Mieke, Kumar, Mayur, Vidler, Jennifer, Lwin, Yadanar, Fields, Paul, Karagiannis, Sophia N., Coolen, Anthony C.C., Rigg, Anne, Papa, Sophie, Hayday, Adrian C., Patten, Piers E.M. and Irshad, Sheeba 2021. Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients. Cancer Cell 39 (2) , pp. 257-275. 10.1016/j.ccell.2021.01.001

Bai, Xuanxuan, Jia, Jianxin, Kang, Qi, Fu, Yadong, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Zhong, Yingbin, Zhang, Chao and Li, Mingyu 2021. Integrated metabolomics and lipidomics analysis reveal remodeling of lipid metabolism and amino acid metabolism in glucagon receptor–deficient zebrafish. Frontiers in Cell and Developmental Biology 8 , 605979. 10.3389/fcell.2020.605979

Qadri, Sami, Lallukka-Brück, Susanna, Luukkonen, Panu K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Gastaldelli, Amalia, Orho-Melander, Marju, Sammalkorpi, Henna, Juuti, Anne, Penttilä, Anne K., Perttilä, Julia, Hakkarainen, Antti, Lehtimäki, Tiina E., Orešič, Matej, Hyötyläinen, Tuulia, Hodson, Leanne, Olkkonen, Vesa M. and Yki-Järvinen, Hannele 2020. The PNPLA3‐I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver International 40 (9) , pp. 2128-2138. 10.1111/liv.14507

Sun, Chao, Wu, Fangda, Wallis, David J. ORCID: https://orcid.org/0000-0002-0475-7583, Shen, Ming Hong ORCID: https://orcid.org/0000-0002-3891-7231, Yuan, Fan, Yang, Jian ORCID: https://orcid.org/0000-0002-8429-7598, Wu, Jianzhong, Xie, Zhihua ORCID: https://orcid.org/0000-0002-5180-8427, Liang, Dongfang, Wang, Hanlin, Tickle, Rowan, Mikhaylov, Roman, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Wu, Zhenlin, Fu, Yongqing, Xun, Wenpeng and Yang, Xin ORCID: https://orcid.org/0000-0002-8429-7598 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67 (8) , pp. 3355-3361. 10.1109/TED.2020.3002498

Ruhanen, Hanna, Naridas, P. A. Nidhina, Minicocci, Ilenia, Taskinen, Juuso H., Palmas, Francesco, di Costanzo, Alessia, D'Erasmo, Laura, Metso, Jari, Partanen, Jennimari, Dalli, Jesmond, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Arca, Marcello, Jauhiainen, Matti, Käkelä, Reijo and Olkkonen, Vesa M. 2020. ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1865 (7) , 158679. 10.1016/j.bbalip.2020.158679

Meckelmann, Sven W., Hawksworth, Jade I., White, Daniel, Andrews, Robert, Rodrigues, Patricia, O'Connor, Anne ORCID: https://orcid.org/0000-0003-2268-4231, Alvarez-Jarreta, Jorge, Tyrrell, Victoria J., Hinz, Christine, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Aldrovandi, Maceler, Watkins, William J. ORCID: https://orcid.org/0000-0003-3262-6588, Engler, Adam J., Lo Sardo, Valentina, Slatter, David A., Allen, Stuart M. ORCID: https://orcid.org/0000-0003-1776-7489, Acharya, Jay, Mitchell, Jacquie, Cooper, Jackie, Aoki, Junken, Kano, Kuniyuki, Humphries, Steve E. and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13 (3) , pp. 149-164. 10.1161/CIRCGEN.119.002806

Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel and Fernández-Real, José M. 2020. Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes. EBioMedicine 53 , 102697. 10.1016/j.ebiom.2020.102697

Liang, Gehao, Ling, Yun, Mehrpour, Maryam, Saw, Phei Er, Liu, Zihao, Tan, Weige, Tian, Zhenluan, Zhong, Wenjing, Lin, Wanyi, Luo, Qing, Lin, Qun, Li, Qiufang, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hamai, Ahmed, Codogno, Patrice, Li, Jun, Song, Erwei and Gong, Chang 2020. Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression. Molecular Cancer 19 (1) , 65. 10.1186/s12943-020-01152-2

Luukkonen, Panu K., Nick, Auli, Hölttä-Vuori, Maarit, Thiele, Christoph, Isokuortti, Elina, Lallukka-Brück, Susanna, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hakkarainen, Antti, Lundbom, Nina, Peltonen, Markku, Orho-Melander, Marju, Oresic, Matej, Hyötyläinen, Tuulia, Hodson, Leanne, Ikonen, Elina and Yki-Järvinen, Hannele 2019. Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight 4 (16) , e127902. 10.1172/jci.insight.127902

Liu, Zihao, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liang, Gehao, Ling, Yun, Tan, Weige, Tan, Luyuan, Andrews, Robert, Zhong, Wenjing, Zhang, Xuanxuan, Song, Erwei and Gong, Chang 2019. Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death and Disease 10 , 55. 10.1038/s41419-018-1287-1

Kentala, Henriikka, Koponen, Annika, Vihinen, Helena, Pirhonen, Juho, Pirhonen, Juho, Liebisch, Gerhard, Pataj, Zoltan, Kivelä, Annukka, Li, Shiqian, Karhinen, Leena, Jääskeläinen, Eeva, Andrews, Robert, Meriläinen, Leena, Matysik, Silke, Ikonen, Elina, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Jokitalo, Eija and Olkkonen, Vesa M. 2018. OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism. Cellular and Molecular Life Sciences 75 (21) , pp. 4041-4057.

Luukkonen, Panu K., Sädevirta, Sanja, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Kayser, Brandon, Ali, Ashfaq, Ahonen, Linda, Lallukka, Susanna, Pelloux, Veronique, Gaggini, Melania, Jian, Ching, Hakkarainen, Antti, Lundbom, Nina, Gylling, Helena, Salonen, Anne, Oresic, Matej, Hyotylainen, Tuulia, Orho-Melander, Marju, Rissanen, Aila, Gastaldelli, Amalia, Clement, Karine, Hodson, Leanne and Yki-Jarvinen, Hannele 2018. Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars. Diabetes Care 41 (8) , pp. 1732-1739. 10.2337/dc18-0071

Aldrovandi, Maceler, Banthiya, Swathi, Meckelmann, Sven, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Heydeck, Dagmar, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 and Kuhn, Hartmut 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863 (2) , pp. 152-164. 10.1016/j.bbalip.2017.11.005

Hua, Bian, Hakkarainen, Antti, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Lundbom, Nina and Yki-Järvinen, Hannele 2018. Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects. Digestive and Liver Disease 50 (2) , pp. 168-174. 10.1016/j.dld.2017.08.030

Kentala, Henriikka, Koponen, Annika, Kivelä, Annukka M., Andrews, Robert, Li, ChunHei, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Olkkonen, Vesa M. 2018. Analysis of ORP2 knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation. FASEB Journal 10.1096/fj.201700604R

Liu, Xijiao, Jiang, Hanyu, Chen, Jie, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Huang, Zixing and Song, Bin 2017. Gadoxetic acid-enhanced MRI outperformed MDCT in diagnosing small hepatocellular carcinoma: A meta-analysis. Liver Transplantation 23 (12) , pp. 1505-1518. 10.1002/lt.24867

Lallukka, Susanna, Sädevirta, Sanja, Kallio, Markus T., Luukkonen, Panu K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hakkarainen, Antti, Lundbom, Nina, Orho-Melander, Marju and Yki-Järvinen, Hannele 2017. Predictors of liver fat and stiffness in non-alcoholic fatty liver disease (NAFLD) - an 11-Year prospective study. Scientific Reports 7 (1) , 14561. 10.1038/s41598-017-14706-0

Isokuortti, Elina, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Peltonen, Markku, Bugianesi, Elisabetta, Clement, Karine, Bonnefont-Rousselot, Dominique, Lacorte, Jean-Marc, Gastaldelli, Amalia, Schuppan, Detlef, Schattenberg, Jörn M., Hakkarainen, Antti, Lundbom, Nina, Jousilahti, Pekka, Männistö, Satu, Keinänen-Kiukaanniemi, Sirkka, Saltevo, Juha, Anstee, Quentin M. and Yki-Järvinen, Hannele 2017. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study. Diabetologia 60 (10) , pp. 1873-1882. 10.1007/s00125-017-4340-1

Mysore, Raghavendra, Liebisch, Gerhard, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Olkkonen, Vesa M. and Nidhina Haridas, P.A. 2017. Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition. Chemistry and Physics of Lipids 207 (B) , pp. 246-252. 10.1016/j.chemphyslip.2017.05.002

Luukkonen, Panu K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Nidhina Haridas, P.A., Dwivedi, Om P., Hyötyläinen, Tuulia, Ali, Ashfaq, Juuti, Anne, Leivonen, Marja, Tukiainen, Taru, Ahonen, Linda, Scott, Emma, Palmer, Jeremy M., Arola, Johanna, Orho-Melander, Marju, Vikman, Petter, Anstee, Quentin M., Olkkonen, Vesa M., Oresic, Matej, Groop, Leif and Yki-Järvinen, Hannele 2017. Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology 67 (1) , pp. 128-136. 10.1016/j.jhep.2017.02.014

Kara, Bülent, Köroğlu, Çiğdem, Peltonen, Karita, Steinberg, Ruchama C, Maras Genç, Hülya, Hölttä-Vuori, Maarit, Güven, Ayse, Kanerva, Kristiina, Kotil, Tugba, Solakoğlu, Seyhun, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Olkkonen, Vesa M, Ikonen, Elina, Laiho, Marikki and Tolun, Aslihan 2017. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. European Journal of Human Genetics 25 (3) , pp. 315-323. 10.1038/ejhg.2016.183

Lallukka, S., Luukkonen, P. K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Petäjä, E. M., Leivonen, M., Juuti, A., Hakkarainen, A., Orho-Melander, M., Lundbom, N., Olkkonen, V. M., Lassila, R. and Yki-Järvinen, H. 2017. Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thrombosis and Haemostasis 2017 (2) , pp. 207-428. 10.1160/TH16-09-0716

Luukkonen, Panu K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Hyötyläinen, Tuulia, Leivonen, Marja, Arola, Johanna, Orho-Melander, Marju, Ore?i?, Matej and Yki-Järvinen, Hannele 2016. The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology 65 (6) , pp. 1263-1265. 10.1016/j.jhep.2016.07.045

Hu, Bang-li, Shi, Cheng, Lei, Rong-e, Lu, Dong-hong, Luo, Wei, Qin, Shan-yu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Jiang, Hai-xing 2016. Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin. Scientific Reports 6 , 36436. 10.1038/srep36436

Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Oresic, Matej, Leivonen, Marja, Gopalacharyulu, Peddinti, Hyysalo, Jenni, Arola, Johanna, Verrijken, An, Francque, Sven, Van Gaal, Luc, Hyötyläinen, Tuulia and Yki-Järvinen, Hannele 2016. Non-invasive detection of non-alcoholic Steatohepatitis using clinical markers and circulating levels of lipids and metabolites. Clinical Gastroenterology and Hepatology 14 (10) , pp. 1463-1472. 10.1016/j.cgh.2016.05.046

Petäjä, E.M., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Peltonen, M., Jouslahti, P., Männistö, S., Keinänen-Kiukaanniemi, S., Saltevo, J. and Yki-Järvinen, H. 2016. Determination of a Normal value for HOMA-IR and cut-off Value for Non-Alcoholic Fatty Liver Disease. Journal of Hepatology 64 (2) , S481. 10.1016/S0168-8278(16)00817-5

Xia, Ming-Feng, Yki-Järvinen, Hannele, Bian, Hua, Lin, Huan-Dong, Yan, Hong-Mei, Chang, Xin-Xia, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Gao, Xin 2016. Influence of ethnicity on the accuracy of non-invasive scores predicting non-alcoholic fatty liver disease. PLoS ONE 11 (8) , e0160526. 10.1371/journal.pone.0160526

Luukkonen, Panu K., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sädevirta, Sanja, Leivonen, Marja, Arola, Johanna, Orešič, Matej, Hyötyläinen, Tuulia and Yki-Järvinen, Hannele 2016. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. Journal of Hepatology 64 (5) , pp. 1167-1175. 10.1016/j.jhep.2016.01.002

Petäjä, Elina M., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Havana, Marika, Hakkarainen, Antti, Lundbom, Nina, Ihalainen, Jarkko and Yki-Järvinen, Hannele 2016. Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD. Scientific Reports 6 , 24740. 10.1038/srep24740

Mysore, Raghavendra, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sädevirta, Sanja, Savolainen-Peltonen, Hanna, Nidhina Haridas, P.A., Soronen, Jarkko, Leivonen, Marja, Sarin, Antti-Pekka, Fischer-Posovszky, Pamela, Wabitsch, Martin, Yki-Järvinen, Hannele and Olkkonen, Vesa M. 2016. MicroRNA-192* impairs adipocyte triglyceride storage. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861 (4) , pp. 342-351. 10.1016/j.bbalip.2015.12.019

Qin, Shan-yu, Lu, Dong-hong, Guo, Xiao-yun, Luo, Wei, Hu, Bang-li, Huang, Xiao-li, Chen, Mei, Wang, Jia-xu, Ma, Shi-Jia, Yang, Xian-wen, Jiang, Hai-xing and Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 2016. A deleterious role for Th9/IL-9 in hepatic fibrogenesis. Scientific Reports 6 , 18694. 10.1038/srep18694

Soronen, Jarkko, Yki- Järvinen, Hannele, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sädevirta, Sanja, Sarin, Antti-Pekka, Leivonen, Marja, Sevastianova, Ksenia, Perttilä, Julia, Laurila, Pirkka?Pekka, Sigruener, Alexander, Schmitz, Gerd and Olkkonen, Vesa M. 2016. Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease. Physiological Reports 4 (1) , e12661. 10.14814/phy2.12661

Hu, Bangli, Luo, Wei, Hu, Rui-Ting, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Qin, Shan-Yu and Jiang, Hai-Xing 2015. Meta-analysis of prognostic and clinical significance of CD44v6 in esophageal cancer. Medicine 94 (31) , e1238. 10.1097/MD.0000000000001238

Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Llauradó, Gemma, Oresic, Matej, Hyötyläinen, Tuulia, Orho-Melander, Marju and Yki-Järvinen, Hannele 2015. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. Journal of Hepatology 62 (3) , pp. 657-663. 10.1016/j.jhep.2014.10.010

Weber-Boyvat, Marion, Kentala, Henriikka, Lilja, Johanna, Vihervaara, Terhi, Hanninen, Raisa, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Peränen, Johan, Nyman, Tuula A., Ivaska, Johanna and Olkkonen, Vesa M. 2015. OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Experimental Cell Research 331 (2) , pp. 278-291. 10.1016/j.yexcr.2014.10.019

Wei, Bingbing, Jin, Wei, Ruan, Jun, Xu, Zhuoqun, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liang, Jiabei, Cheng, Huan, Jin, Ke, Huang, Xing, Lu, Peng and Hu, Qiang 2015. Cripto-1 expression and its prognostic value in human bladder cancer patients. Tumor Biology 36 (2) , pp. 1105-1113. 10.1007/s13277-014-2695-1

Bian, Hua, Hakkarainen, Antti, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Lundbom, Nina, Olkkonen, Vesa M and Yki-Järvinen, Hannele 2015. Impact of non-alcoholic fatty liver disease on liver volume in humans. Hepatology Research 45 (2) , pp. 210-219. 10.1111/hepr.12338

Lu, Jie-fu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Huang, Gui-hua, Jiang, Hai-xing, Hu, Bang-li and Qin, Shan-yu 2014. Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis. Human Immunology 75 (10) , pp. 1062-1068. 10.1016/j.humimm.2014.09.004

Qin, Shan-yu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Li, Ping and Jiang, Hai-xing 2014. Diagnostic efficacy of cell block immunohistochemistry, smear cytology, and liquid-based cytology in endoscopic ultrasound-guided fine-needle aspiration of pancreatic lesions: a single-institution experience. PLoS ONE 9 (9) , e108762. 10.1371/journal.pone.0108762

Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Wohlfahrt, Gerd, Paavola, Jere and Olkkonen, Vesa M. 2014. A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human. Biochemical and Biophysical Research Communications 446 (3) , pp. 675-680. 10.1016/j.bbrc.2013.12.002

Hyysalo, Jenni, Männistö, Ville T., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Arola, Johanna, Kärjä, Vesa, Leivonen, Marja, Juuti, Anne, Jaser, Nabil, Lallukka, Susanna, Käkelä, Pirjo, Venesmaa, Sari, Simonen, Marko, Saltevo, Juha, Moilanen, Leena, Korpi-Hyövalti, Eeva, Keinänen-Kiukaanniemi, Sirkka, Oksa, Heikki, Orho-Melander, Marju, Valenti, Luca, Fargion, Silvia, Pihlajamäki, Jussi, Peltonen, Markku and Yki-Järvinen, Hannele 2014. A population-based study on the prevalence of NASH using scores validated against liver histology. Journal of Hepatology 60 (4) , pp. 839-846. 10.1016/j.jhep.2013.12.009

Qin, Shanyu, Ma, Shijia, Huang, Xiaoli, Lu, Donghong, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Jiang, Haixing 2014. Th22 cells are associated with hepatocellular carcinoma development and progression. Chinese Journal of Cancer Research 26 (2) , pp. 135-141. 10.3978/j.issn.1000-9604.2014.02.14

Zhong, Wenbin, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Li, Jiwei, Mysore, Raghavendra, Luo, Wei, Li, Shiqian, Chang, Mau-Sun, Olkkonen, Vesa M. and Yan, Daoguang 2014. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Experimental Cell Research 322 (2) , pp. 227-235. 10.1016/j.yexcr.2014.01.002

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Yki-Jarvinen, H., Ikonen, E., Kakela, R. and Olkkonen, V. M. 2014. PNPLA3 mediates hepatocyte triacylglycerol remodeling. Journal of Lipid Research 55 (4) , pp. 739-746. 10.1194/jlr.M046607

Wang, Junli, Nong, Legen, Wei, Yesheng, Qin, Shanyu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Tang, Yujin 2014. Association of osteopontin polymorphisms with nasopharyngeal carcinoma risk. Human Immunology 75 (1) , pp. 76-80. 10.1016/j.humimm.2013.09.014

Qin, Shan-Yu, Jiang, Hai-Xing, Lu, Dong-Hong and Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 2013. Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: A meta-analysis. World Journal of Gastroenterology 19 (48) , pp. 9472-9480. 10.3748/wjg.v19.i48.9472

Wang, Junli, Nong, Legen, Wei, Yesheng, Qin, Shanyu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Tang, Yujin 2013. Association of interleukin-12 polymorphisms and serum IL-12p40 levels with osteosarcoma risk. DNA and Cell Biology 32 (10) , pp. 605-610. 10.1089/dna.2013.2098

Qin, Shan-yu, Liu, Jie, Jiang, Hai-xing, Hu, Bang-li, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291 and Olkkonen, Vesa M. 2013. Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies. Atherosclerosis 227 (2) , pp. 360-366. 10.1016/j.atherosclerosis.2013.01.014

Ruan, Jun, Wei, Bingbing, Xu, Zhuoqun, Yang, Shudong, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Yu, Minhong, Liang, Jiabei, Jin, Ke, Huang, Xing, Lu, Peng and Cheng, Huan 2013. Predictive value of Sox2 expression in transurethral resection specimens in patients with T1 bladder cancer. Medical Oncology 30 (1) , 445. 10.1007/s12032-012-0445-z

Li, Fei, Chen, Ding-nan, He, Cheng-wu, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Olkkonen, Vesa M., He, Nan, Chen, Wei, Wan, Pei, Chen, San-san, Zhu, Yong-tong, Lan, Kai-jian and Tan, Wan-long 2012. Identification of urinary Gc-globulin as a novel biomarker for bladder cancer by two-dimensional fluorescent differential gel electrophoresis (2D-DIGE). Journal of Proteomics 77 , pp. 225-236. 10.1016/j.jprot.2012.09.002

Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Robciuc, Marius R., Wabitsch, Martin, Juuti, Anne, Leivonen, Marja, Ehnholm, Christian, Yki-Järvinen, Hannele and Olkkonen, Vesa M. 2012. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: Evidence for impacts on the adipocyte phenotype. PLoS ONE 7 (9) , e45352. 10.1371/journal.pone.0045352

Olkkonen, Vesa M., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Yan, Daoguang and Vihervaara, Terhi 2012. Oxysterol-binding proteins-emerging roles in cell regulation. European Journal of Lipid Science and Technology 114 (6) , pp. 634-643. 10.1002/ejlt.201200044

Li, Fei, An, Sheng-li, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Liang, Zhong-kun, Jiao, Zhan-jiang, Jing, Yu-ming, Wan, Pei, Shi, Xiao-jun and Tan, Wan-long 2011. Milk and dairy consumption and risk of bladder cancer: a Meta-analysis. Urology 78 (6) , pp. 1298-1305. 10.1016/j.urology.2011.09.002

Zhong, Wenbin, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Li, Shiqian, Zhou, Tianhong, Ma, Hongling, Wei, Kunde, Li, Hongye, Olkkonen, Vesa M. and Yan, Daoguang 2011. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Experimental Cell Research 317 (16) , pp. 2353-2363. 10.1016/j.yexcr.2011.05.028

Wei, B., Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Xu, Z., Ruan, J., Zhu, M., Jin, K., Zhou, D., Hu, Q., Wang, Q., Wang, Z. and Yan, Z. 2011. XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis. Prostate Cancer and Prostatic Diseases 14 (3) , pp. 225-231. 10.1038/pcan.2011.26

Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Li, Shiqian, Mäyränpää, Mikko I., Zhong, Wenbin, Bäck, Nils, Yan, Daoguang and Olkkonen, Vesa M. 2010. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. Experimental Cell Research 316 (19) , pp. 3304-3316. 10.1016/j.yexcr.2010.06.008

Wu, Xiaoyun, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Zhang, Ke, Liu, Qingzhen and Guo, Deyin 2008. Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Letters 582 (15) , pp. 2155-2160. 10.1016/j.febslet.2008.05.033