Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice

Pittenger, Christopher, Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139, Mazzocchi-Jones, David Martin, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Kandel, Eric R. and Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 2006. Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice. Journal of Neuroscience 26 (10) , pp. 2808-2813. 10.1523/JNEUROSCI.5406-05.2006

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Abstract

The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood. We examined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords:	striatum ; memory formation ; learning and memory ; transgenic ; synaptic plasticity ; genetics
Additional Information:	“Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.(”http://creativecommons.org/licenses/) See: http://www.jneurosci.org/site/misc/ifa_policies.xhtml
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Last Modified:	06 May 2023 16:16
URI:	https://orca.cardiff.ac.uk/id/eprint/1128

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