Inference of transition probabilities between the attractors in Boolean networks with perturbation

Yu, Le, Watterson, Steven, Marshall, Stephen and Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 2009. Inference of transition probabilities between the attractors in Boolean networks with perturbation. Presented at: 2009 IEEE International Workshop on Genomic Signal Processing and Statistics, Minneapolis, MN, USA, 17-21 May 2009. 2009 IEEE International Workshop on Genomic Signal Processing and Statistics. IEEE, 10.1109/GENSIPS.2009.5174376

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Abstract

This paper investigates the inference of Boolean networks with perturbation (BNp) from simulated data and observed data. We interpret the discretised gene expression levels as attractor states of the underlying network and use the sequence of attractor states to determine the model. We consider the case where a complete sequence of attractors is known and the case where the known attractor states are arrived at by sampling from an underlying sequence of attractors. We apply the resulting algorithm to the interferon regulatory network using gene expression data taken from murine bone-derived macrophage cells infected with cytomegalovirus.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	IEEE
ISBN:	9781424447619
Last Modified:	23 Oct 2022 14:16
URI:	https://orca.cardiff.ac.uk/id/eprint/113226

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