Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus

Busche, Andreas, Angulo, Ana, Kay-Jackson, Penelope, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 and Messerle, Martin 2008. Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus. Medical Microbiology and Immunology 197 (2) , pp. 233-240. 10.1007/s00430-008-0076-3

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Abstract

Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection. Here we summarize the current results on the characterization of these mutants and give a perspective of the future research in this field.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Springer Verlag (Germany)
ISSN:	0300-8584
Last Modified:	23 Oct 2022 14:17
URI:	https://orca.cardiff.ac.uk/id/eprint/113287

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