A logic-based diagram of signalling pathways central to macrophage activation

Raza, Sobia, Robertson, Kevin A, Lacaze, Paul A, Page, David, Enright, Anton J, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 and Freeman, Tom C 2008. A logic-based diagram of signalling pathways central to macrophage activation. BMC Systems Biology 2 (1) , 36. 10.1186/1752-0509-2-36

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Abstract

Background The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-κB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions. Results Here we describe the construction of a logically represented pathway diagram which attempts to integrate these four pathways central to innate immunity using a modified version of the Edinburgh Pathway Notation. The pathway map is available in a number of electronic formats and editing is supported by yEd graph editor software. Conclusion The map presents a powerful visual aid for interpreting the available pathway interaction knowledge and underscores the valuable contribution well constructed pathway diagrams make to communicating large amounts of molecular interaction data. Furthermore, we discuss issues with the limitations and scalability of pathways presented in this fashion, explore options for automated layout of large pathway networks and demonstrate how such maps can aid the interpretation of functional studies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	BioMed Central
ISSN:	1752-0509
Date of First Compliant Deposit:	23 August 2018
Date of Acceptance:	23 April 2008
Last Modified:	05 May 2023 22:50
URI:	https://orca.cardiff.ac.uk/id/eprint/113289

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