Hijacking and exploitation of IL-10 by intracellular pathogens

Redpath, Stella, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 and Gascoigne, Nicholas R.J 2001. Hijacking and exploitation of IL-10 by intracellular pathogens. Trends in Microbiology 9 (2) , pp. 86-92. 10.1016/S0966-842X(00)01919-3

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Abstract

Macrophages play a central role in infections, as a target for pathogens and in activation of the immune system. Interleukin-10 (IL-10), a cytokine produced by macrophages, is a potent immunosuppressive factor. Some intracellular pathogens specifically target macrophages for infection and use IL-10 to dampen the host immune response and stall their elimination from the host. Certain viruses induce production of cellular IL-10 by macrophages, whereas other viruses encode their own viral IL-10 homologs. Additionally, specific bacteria, including several Mycobacteria spp. and Listeria monocytogenes, can survive and replicate in macrophages while inducing cellular IL-10, highlighting a potential role for IL-10 of macrophage origin in the immunosuppressive etiology of these pathogens. Thus, the exploitation of IL-10 appears to be a common mechanism of immunosuppression by a diverse group of intracellular pathogens that can infect macrophages.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0966-842X
Last Modified:	23 Oct 2022 14:23
URI:	https://orca.cardiff.ac.uk/id/eprint/113510

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