Godfrey, Dale I., Le Nours, Jérôme, Andrews, Daniel M., Uldrich, Adam P. and Rossjohn, Jamie ![]() ![]() |
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Abstract
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which interact with MHC class Ib and MHC-I like molecules, are also implicated in tumor immunity, although their role therein is unclear. These include unconventional T cells targeting MHC class Ib molecules such as HLA-E and its murine ortholog Qa-1b, natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, and γδ T cells. Here, we review the current understanding of the roles of these unconventional T cells in tumor immunity and discuss why further studies into the immunotherapeutic potential of these cells is warranted
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Elsevier (Cell Press) |
ISSN: | 1074-7613 |
Date of First Compliant Deposit: | 16 April 2019 |
Last Modified: | 12 Nov 2023 03:34 |
URI: | https://orca.cardiff.ac.uk/id/eprint/117748 |
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