Shirinzadeh, Hanif, Suzen, Sibel, Altanlar, Nurten and Westwell, Andrew  ORCID: https://orcid.org/0000-0002-5166-9236
2018.
Antimicrobial activities of new indole derivatives containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide.
The Turkish Journal of Pharmaceutical Sciences
15
(3)
, pp. 291-297.
10.4274/tjps.55707
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Abstract
Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 μg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Pharmacy |
| ISSN: | 1304-530X |
| Date of First Compliant Deposit: | 11 March 2019 |
| Date of Acceptance: | 19 October 2017 |
| Last Modified: | 06 May 2023 12:52 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/120509 |
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