Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate

Yu, Fanglei, Miller, David James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate. Chemical Communications- Royal Society of Chemistry (40) , pp. 4155-4157. 10.1039/b709562g

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Abstract

12,13-Difluorofarnesyl diphosphate, prepared using Suzuki–Miyaura chemistry, is a potent inhibitor of aristolochene synthase (AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction.

Item Type:	Article
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Last Modified:	18 Oct 2022 13:08
URI:	https://orca.cardiff.ac.uk/id/eprint/12484

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