Ward, Simon E.  ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark H., Aldegheri, Laura, Bradford, Andrea M., Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X and Woolley, Marie
2020.
Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile.
Journal of Psychopharmacology
34
(1)
, pp. 93-102.
10.1177/0269881119872198
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Abstract
There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disorders. However, the challenge is to increase AMPA receptor (AMPAR) function sufficient to enhance cognitive function but not to the extent that there are mechanism-related pro-convulsant or convulsant side effects. In this present study, we report the preclinical pharmacology data for MDI-222, an AMPAR PAM which enhances cognition but has a much reduced side-effect (i.e. convulsant) liability relative to other molecules of this mechanism.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Schools > Biosciences |
| Publisher: | SAGE |
| ISSN: | 0269-8811 |
| Date of First Compliant Deposit: | 2 January 2020 |
| Date of Acceptance: | 28 July 2019 |
| Last Modified: | 29 Nov 2024 22:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/128151 |
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