ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Jimenez-Pascual, Ana, Lathia, Justin D. and Siebzehnrubl, Florian A. ORCID: https://orcid.org/0000-0001-8411-8775 2019. ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & Cellular Oncology 7 (1) , 1684787. 10.1080/23723556.2019.1684787

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Abstract

Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor autocrine signaling loop, which can be blocked pharmacologically.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Biosciences Research Institutes & Centres > European Cancer Stem Cell Research Institute (ECSCRI)
ISSN:	2372-3556
Date of First Compliant Deposit:	13 January 2020
Date of Acceptance:	22 October 2019
Last Modified:	16 Nov 2024 01:00
URI:	https://orca.cardiff.ac.uk/id/eprint/128458

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