Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

Dennison, Charlotte A. ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie E., Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590 and Walters, James T.R. ORCID: https://orcid.org/0000-0002-6980-4053 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217 , pp. 4-12. 10.1016/j.schres.2019.10.048

Preview

PDF - Accepted Post-Print Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (343kB) | Preview

Abstract

Genome-wide association studies (GWAS) have proved to be a powerful approach for gene discovery in schizophrenia; their findings have important implications not just for our understanding of the genetic architecture of the disorder, but for the potential applications of personalised medicine through improved classification and targeted interventions. In this article we review the current status of the GWAS literature in schizophrenia including functional annotation methods and polygenic risk scoring, as well as the directions and challenges of future research. We consider recent findings in East Asian populations and the advancements from trans-ancestry analysis, as well as the insights gained from research looking across psychiatric disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	0920-9964
Date of First Compliant Deposit:	22 January 2020
Date of Acceptance:	25 October 2019
Last Modified:	12 Nov 2024 02:30
URI:	https://orca.cardiff.ac.uk/id/eprint/128946

Citation Data

Cited 25 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item