El-Betany, Alaa M.M. ![]() ![]() ![]() |
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Abstract
The epithelial permeation of water-soluble fluorescent PAMAM dendrons based on 7H-benz[de] benzimidazo [2,1-a] isoquinoline-7-one as a fluorescent core across epithelial cell models MDCK I and MDCK II has been quantified. Hydrodynamic radii have been derived from self-diffusion coefficients obtained via pulsed-gradient spin-echo Nuclear Magnetic Resonance (PGSE-NMR). Results indicate that these dendritic molecules are molecularly disperse, non-aggregating, and only slightly larger than their parent homologues. MDCK I permeability studies across epithelial barriers show that these dendritic molecules are biocompatible with the chosen epithelial in-vitro model and can permeate across MDCK cell monolayers. Permeability is demonstrated to be a property of dendritic size and cell barrier restrictiveness indicating that paracellular mechanisms play the predominant role in the transport of these molecules.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Pharmacy Chemistry |
Publisher: | Elsevier |
ISSN: | 0378-5173 |
Date of First Compliant Deposit: | 11 March 2020 |
Date of Acceptance: | 26 February 2020 |
Last Modified: | 11 Sep 2024 20:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/130325 |
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