Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences

El-Betany, Alaa M.M. ORCID: https://orcid.org/0000-0002-5990-1001, Kamoun, Elbadawy A., James, Craig ORCID: https://orcid.org/0000-0002-0569-182X, Jangher, Abdulhakim, Aljayyoussi, Ghaith, Griffiths, Peter, McKeown, Neil B. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2020. Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences. International Journal of Pharmaceutics 579 , 119187. 10.1016/j.ijpharm.2020.119187

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Abstract

The epithelial permeation of water-soluble fluorescent PAMAM dendrons based on 7H-benz[de] benzimidazo [2,1-a] isoquinoline-7-one as a fluorescent core across epithelial cell models MDCK I and MDCK II has been quantified. Hydrodynamic radii have been derived from self-diffusion coefficients obtained via pulsed-gradient spin-echo Nuclear Magnetic Resonance (PGSE-NMR). Results indicate that these dendritic molecules are molecularly disperse, non-aggregating, and only slightly larger than their parent homologues. MDCK I permeability studies across epithelial barriers show that these dendritic molecules are biocompatible with the chosen epithelial in-vitro model and can permeate across MDCK cell monolayers. Permeability is demonstrated to be a property of dendritic size and cell barrier restrictiveness indicating that paracellular mechanisms play the predominant role in the transport of these molecules.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Chemistry
Publisher:	Elsevier
ISSN:	0378-5173
Date of First Compliant Deposit:	11 March 2020
Date of Acceptance:	26 February 2020
Last Modified:	06 Nov 2024 21:30
URI:	https://orca.cardiff.ac.uk/id/eprint/130325

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