Nödling, Alexander R., Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Williams, Thomas L., Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2020. Enabling protein-hosted organocatalytic transformations. RSC Advances 10 (27) , pp. 16147-16161. 10.1039/D0RA01526A |
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Official URL: http://dx.doi.org/10.1039/D0RA01526A
Abstract
In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 2046-2069 |
Funders: | Leverhulme Trust, Royal Society, Wellcome Seed Trust |
Date of First Compliant Deposit: | 23 April 2020 |
Date of Acceptance: | 25 March 2020 |
Last Modified: | 07 Jun 2023 20:34 |
URI: | https://orca.cardiff.ac.uk/id/eprint/131196 |
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