Browse by Current Cardiff authors

Tang, T. M. Simon and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2024. Towards controlling activity of a peptide asparaginyl ligase (PAL) by lumazine synthetase compartmentalization. Faraday Discussions 252 , pp. 403-421. 10.1039/D4FD00002A

Abramiuk, Magdalena, Acevedo-Rocha, Carlos, Alogaidi, Abdulrahman, Armstrong, Fraser, Bakshi, Amulyasai, Bornscheuer, Uwe T., Campopiano, Dominic J., Chaiyen, Pimchai, Ehinger, Friedrich Johannes, Flitsch, Sabine, Harvey, Jeremy N., Hilvert, Donald, Jarvis, Amanda G., Jones, Rhiannon E. H., Lichtenstein, Bruce R., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Lurshay, Tara C., Malcomson, Thomas, Marsh, E. Neil G., McFarlane, Neil R., McKenzie, Alexander, Megarity, Clare F., Moliner, Vicent, Mulholland, Adrian J., Orton, Ben, Pelletier, Joelle N., Raczynska, Agata, Syrén, Per-Olof, Thompson, Sean Adeoti, Turner, Nicholas, Valetti, Francesca, Wong, Lu Shin and Zeymer, Cathleen 2024. Biocatalytic pathways, cascades, cells and systems: general discussion. Faraday Discussions 252 , pp. 241-261. 10.1039/D4FD90023E

Williams, Thomas L. ORCID: https://orcid.org/0000-0003-1710-3914, Taily, Irshad M., Hatton, Lewis, Berezin, Andrey A, Wu, Yi‐Lin ORCID: https://orcid.org/0000-0003-0253-1625, Moliner, Vicent, Świderek, Katarzyna, Tsai, Yu‐Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2024. Secondary amine catalysis in enzyme design: broadening protein template diversity through genetic code expansion. Angewandte Chemie International Edition 10.1002/anie.202403098

Lander, Alexander J., Kong, Yifu, Jin, Yi, Wu, Chuanliu and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2024. Deciphering the synthetic and refolding strategy of a cysteine-rich domain in the tumor necrosis factor receptor (TNF-R) for racemic crystallography analysis and d-peptide ligand discovery. ACS Bio & Med Chem Au 4 (1) , pp. 68-76. 10.1021/acsbiomedchemau.3c00060

Ma, Muge, Tang, Simon T.M., Dickerson, Matthew T. and Luk, Louis Y.P. ORCID: https://orcid.org/0000-0002-7864-6261 2023. Preparing recombinant “Split AEP” for protein labeling. Lloyd, Matthew, ed. Methods in Enzymology, Vol. 690. Methods in Enzymology, Elsevier, pp. 501-540. (10.1016/bs.mie.2023.07.004)

Lander, Alexander J., Mercado, Laura Domínguez, Li, Xuefei, Taily, Irshad Maajid, Findlay, Brandon L., Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2023. Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography. Communications Chemistry 6 (1) , 154. 10.1038/s42004-023-00953-y

Cardella, Davide, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2023. Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins. Organic and Biomolecular Chemistry 21 , pp. 966-969. 10.1039/d2ob02198f

Hayes, Heather C. and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2023. Investigating the effects of cyclic topology on the performance of a plastic degrading enzyme for polyethylene terephthalate degradation. Scientific Reports 13 , 1267. 10.1038/s41598-023-27780-4

Lander, Alexander J., Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2022. D‐peptide and d‐protein technology: recent advances, challenges, and opportunities. ChemBioChem , e202200537. 10.1002/cbic.202200537

Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Samperio, Raquel, Mart, Robert ORCID: https://orcid.org/0000-0003-2196-5840, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088, Jones, Arwyn ORCID: https://orcid.org/0000-0003-2781-8905 and Cruz Samperio, Raquel 2022. Spatio-temporal control of cell death by selective delivery of photo-activatable proteins. ChemBioChem 23 (12) , e202200115. 10.1002/cbic.202200115

Cardella, Davide, Deng, Wenjing, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2022. Effect of trimethine cyanine dye- and folate-conjugation on the in vitro biological activity of proapoptotic peptides. Biomolecules 12 (5) , 725. 10.3390/biom12050725

Galmés, Miquel À., Nodling, Alexander R., He, Kaining, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Swiderek, Katarzyna and Moliner, Vicent 2022. Computational design of an amidase by combining the best electrostatic features of two promiscuous hydrolases. Chemical Science 13 (17) , pp. 4779-4787. 10.1039/D2SC00778A

Nodling, Alexander Roland, Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Castillo, Raquel, Lipka-Lloyd, Magdalena, Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Morrill, Louis Christian ORCID: https://orcid.org/0000-0002-6453-7531, Swiderek, Katarzyna, Moliner, Vicent and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2021. The role of protein environment in catalysis by biotinylated secondary amines. Organic and Biomolecular Chemistry 19 , pp. 10424-10431. 10.1039/D1OB01947C

Galmés, Miquel À., Nodling, Alexander R., Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Swiderek, Katarzyna and Moliner, Vicent 2021. Combined theoretical and experimental study to unravel the differences in promiscuous amidase activity of two nonhomologous enzymes. ACS Catalysis 11 (14) , pp. 8635-8644. 10.1021/acscatal.1c02150

Adesina, Aduragbemi S., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2021. Cryo‐kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductase. ChemBioChem 22 (14) , pp. 2410-2414. 10.1002/cbic.202100017

Tang, Tsz Man Simon Louis and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2021. Asparaginyl endopeptidases: enzymology, applications and limitations. Organic and Biomolecular Chemistry 19 (23) , pp. 5048-5062. 10.1039/D1OB00608H

Hayes, Heather C., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2021. Approaches for peptide and protein cyclisation. Organic and Biomolecular Chemistry 19 (18) , pp. 3983-4001. 10.1039/D1OB00411E

Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Morrill, Louis Christian ORCID: https://orcid.org/0000-0002-6453-7531, Swiderek, Katarzyna, Moliner, Vicent and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2021. Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalyst. Chemical Communications 57 (15) , pp. 1919-1922. 10.1039/D0CC08142F

Williams, Thomas L., Iskandar, Debra J., Nödling, Alexander R., Tan, Yurong, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2021. Transferability of N-terminal mutations of pyrrolysyl-tRNA synthetase in one species to that in another species on unnatural amino acid incorporation efficiency. Amino Acids 53 , pp. 89-96. 10.1007/s00726-020-02927-z

Thomas, Sophie R., Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384, Escudero Sanchez, Jorge, Meier-Menches, Samuel M., Brown, Christopher, Wolf, Mike, Barone, Giampaolo, Luk, Louis Y. ORCID: https://orcid.org/0000-0002-7864-6261 and Casini, Angela 2020. Exploring the chemoselectivity towards cysteine arylation by cyclometalated Au(III) compounds: new mechanistic insights. ChemBioChem 21 (21) , pp. 3071-3076. 10.1002/cbic.202000262

Adesina, Aduragbemi S., Swiderek, Katarzyna, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2020. Electric field measurements reveal the pivotal role of Cofactor-Substrate interaction in dihydrofolate reductase catalysis. ACS Catalysis 10 (14) , pp. 7907-7914. 10.1021/acscatal.0c01856

Tang, T. M. Simon, Cardella, Davide, Lander, Alexander J., Li, Xuefei, Escudero, Jorge S., Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2020. Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling. Chemical Science 11 (23) , pp. 5881-5888. 10.1039/D0SC02023K

Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2020. Streptavidin-hosted organocatalytic aldol addition. Molecules 25 (10) , 2457. 10.3390/molecules25102457

Nödling, Alexander, Mills, Emily M., Li, Xuefei, Cardella, Davide, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Wu, Shih-Hsiung, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56 (34) , pp. 4672-4675. 10.1039/C9CC07931A

Nödling, Alexander R., Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Williams, Thomas L., Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2020. Enabling protein-hosted organocatalytic transformations. RSC Advances 10 (27) , pp. 16147-16161. 10.1039/D0RA01526A

Zheng, Xiaoli, Li, Zhuoru, Gao, Wei, Meng, Xiaoting, Li, Xuefei, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Zhao, Yibing, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Wu, Chuanliu 2020. Condensation of 2-((Alkylthio)(aryl)methylene)malononitrile with 1,2-Aminothiol as a novel bioorthogonal reaction for site-specific protein modification and peptide cyclization. Journal of the American Chemical Society 142 (11) , pp. 5097-5103. 10.1021/jacs.9b11875

Mills, Emily M., Barlow, Victoria L., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2020. Applying switchable Cas9 variants to in vivo gene editing for therapeutic applications. Cell Biology and Toxicology 36 , pp. 17-29. 10.1007/s10565-019-09488-2

Meier-Menches, Samuel M., Aikman, Brech, Döllerer, Daniel, Klooster, Wim T., Coles, Simon J., Santi, Nicolò ORCID: https://orcid.org/0000-0001-6361-5457, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 and Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384 2020. Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands. Journal of Inorganic Biochemistry 202 , 110844. 10.1016/j.jinorgbio.2019.110844

Allemann, Rudolf K ORCID: https://orcid.org/0000-0002-1323-8830, Scott, Alan F., Luk, Louis Y.-P. ORCID: https://orcid.org/0000-0002-7864-6261, Tuñón, Iñaki and Moliner, Vicent 2019. Heavy enzymes and the rational redesign of protein catalysts. ChemBioChem 20 (22) , pp. 2807-2812. 10.1002/cbic.201900134

Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Loss of hyperconjugative effects drives hydride transfer during dihydrofolate reductase catalysis. ACS Catalysis 9 (11) , pp. 10343-10349. 10.1021/acscatal.9b02839

Nodling, Alexander R., Spear, Luke A., Williams, Thomas L., Luk, Louis Y.P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2019. Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells. Essays in Biochemistry 63 (2) , pp. 237-266. 10.1042/EBC20180042

Scott, Alan F., Cresser-Brown, Joel, Williams, Thomas L., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Luk, Louis Y.-P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Crystal structure and biophysical analysis of furfural detoxifying aldehyde reductase from clostridium beijerinkii. Applied and Environmental Microbiology 10.1128/AEM.00978-19

Patel, Sanjay G., Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9 (1) , -. 10.1038/s41598-019-42456-8

Nodling, Alexander R., Swiderek, Katarzyna, Castillo, Raquel, Hall, Jonathan W., Angelastro, Antonio, Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531, Jin, Yi, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088, Moliner, Vicent and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2018. Reactivity and selectivity of iminium organocatalysis improved by a protein host. Angewandte Chemie International Edition 57 (38) , pp. 12478-12482. 10.1002/anie.201806850

Williams, Thomas L., Nodling, Alexander, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 2018. Carbapenems as water soluble organocatalysts. Wellcome Open Research 2018 (3) , 107. 10.12688/wellcomeopenres.14721.1

Suzuki, Toru, Asami, Maki, Patel, Sanjay G., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Perry, Anthony C. F. 2018. Switchable genome editing via genetic code expansion. Scientific Reports 8 (1) , 10051. 10.1038/s41598-018-28178-3

Behiry, Enas M., Ruiz-Pernia, J. Javier, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Tunon, Inaki, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2018. Isotope substitution of promiscuous alcohol dehydrogenase reveals the origin of substrate preference in the transition state. Angewandte Chemie International Edition 57 (12) , pp. 3128-3131. 10.1002/anie.201712826

Świderek, Katarzyna, Nödling, Alexander, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261 and Moliner, Vicent 2018. Reaction mechanism of organocatalytic Michael addition of nitromethane to cinnamaldehyde: a case study on catalyst regeneration and solvent effects. Journal of Physical Chemistry A 122 (1) , pp. 451-459. 10.1021/acs.jpca.7b11803

Liao, Jiahn-Haur, Tsai, Cheng-Han, Patel, Sanjay G., Yang, Jhih-Tian, Tu, I-Fan, Lo Cicero, Matteo, Lipka-Lloyd, Magdalena, Wu, Wan-Ling, Shen, Wen-Jie, Ho, Meng-Ru, Chou, Chi-Chi, Sharma, Garima R., Okanishi, Hiroki, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Wu, Shih-Hsiung 2017. Acetylome of acinetobacter baumannii SK17 reveals a highly-conserved modification of histone-like protein HU. Frontiers in Molecular Biosciences 4 , 77. 10.3389/fmolb.2017.00077

Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Dawson, William M., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, E. Joel and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. Chemoenzymatic assembly of isotopically labeled folates. Journal of the American Chemical Society 139 (37) , pp. 13047-13054. 10.1021/jacs.7b06358

Wilkins, Lewis C., Santi, Nicolo ORCID: https://orcid.org/0000-0001-6361-5457, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 2017. Reactions of biologically inspired hydride sources with B(C6F5)3. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375 (2101) , 20170009. 10.1098/rsta.2017.0009

Scott, Alan F., Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Chemical ligation and isotope labeling to locate dynamic effects. Imperiali, Barbara, ed. Methods in Enzymology, Vol. 596. Elsevier, pp. 23-41. (10.1016/bs.mie.2017.06.040)

Lai, Shu-Jung, Tu, I-Fan, Wu, Wan-Ling, Yang, Jhih-Tian, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Lai, Mei-Chin, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Wu, Shih-Hsiung 2017. Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. BMC Microbiology 17 (1) , 123. 10.1186/s12866-017-1034-2

Loveridge, Edric Joel, Hroch, Lukas, Hughes, Robert L., Williams, Thomas, Davies, Rhidian L., Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Maglia, Giovanni and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Reduction of folate by dihydrofolate reductase from thermotoga maritima. Biochemistry 56 (13) , pp. 1879-1886. 10.1021/acs.biochem.6b01268

Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Dawson, William M., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. A versatile disulfide-driven recycling system for NADP+ with high cofactor turnover number. ACS Catalysis 7 (2) , pp. 1025-1029. 10.1021/acscatal.6b03061

Castillo, Juan P., Sánchez-Rodríguez, Jorge E., Hyde, H. Clark, Zaelzer, Cristian A., Aguayo, Daniel, Sepúlveda, Romina V., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Kent, Stephen B. H., Gonzalez-Nilo, Fernando D., Bezanilla, Francisco and Latorre, Ramón 2016. β1-subunit–induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. Proceedings of the National Academy of Sciences 113 (23) , E3231-E3239. 10.1073/pnas.1606381113

Ruiz-Pernía, J. Javier, Behiry, Enas, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2016. Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7 (5) , pp. 3248-3255. 10.1039/C5SC04209G

Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernía, J. Javier, Adesina, Aduragbemi S., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vincent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2015. Chemical ligation and isotope labeling to locate dynamic effects during catalysis by dihydrofolate reductase. Angewandte Chemie International Edition 54 (31) , pp. 9016-9020. 10.1002/anie.201503968

Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2015. Protein motions and dynamic effects in enzyme catalysis. Physical Chemistry Chemical Physics 17 , pp. 30817-30827. 10.1039/C5CP00794A

Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Loveridge, Edric and Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 2015. Protein motions, dynamic effects and thermal stability in dihydrofolate reductase from the hyperthermophile thermotoga maritima. Olivares-Quiroz, Luis, Guzmán-López, Orlando and Jardón-Valadez, Hector Eduardo, eds. Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation, Springer International Publishing, pp. 99-113. (10.1007/978-3-319-21687-4_6)

Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernia, J. Javier, Dawson, William M., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2014. Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic com-pensatory effects on the rate constant. Journal of the American Chemical Society 136 (49) , pp. 17317-17323. 10.1021/ja5102536

Behiry, Enas Mamdouh, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Matthews, Stella M., Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2014. Role of the occluded conformation in bacterial dihydrofolate reductases. Biochemistry 53 (29) , pp. 4761-4768. 10.1021/bi500507v

Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, E. Joel and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2014. Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases. Journal of the American Chemical Society 136 (19) , pp. 6862-6865. 10.1021/ja502673h

Guo, Jian Nan, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2014. Thermal adaptation of dihydrofolate reductase from the moderate thermophile geobacillus stearothermophilus. Biochemistry 53 (17) , pp. 2855-2863. 10.1021/bi500238q

Ruiz-Pernia, J. Javier, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Garcia-Meseguer, Rafael, Martí, Sergio, Loveridge, Edric Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society 135 (49) , pp. 18689-18696. 10.1021/ja410519h

Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernia, J. Javier, Dawson, William Michael, Roca, Maite, Loveridge, Edric Joel, Glowacki, David R., Harvey, Jeremy N., Mulholland, Adrian J., Tunon, Inaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis. Proceedings of the National Academy of Sciences of the United States of America 110 (41) , pp. 16344-16349. 10.1073/pnas.1312437110

Guo, Jiannan, Loveridge, Edric Joel, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Effect of dimerization on dihydrofolate reductase catalysis. Biochemistry 52 (22) , pp. 3881-3887. 10.1021/bi4005073

Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Qian, Qi and Tanner, Martin E. 2011. A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase? Journal of the American Chemical Society 133 (32) , pp. 12342-12345. 10.1021/ja2034969

Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 and Tanner, Martin E. 2009. Mechanism of dimethylallyltryptophan synthase: Evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction. Journal of the American Chemical Society 131 (39) , pp. 13932-13933. 10.1021/ja906485u

Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Bunn, Shannon, Liscombe, David K., Facchini, Peter J. and Tanner, Martin E. 2007. Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis:  An enzymatic Pictet-Spengler reaction. Biochemistry 46 (35) , pp. 10153-10161. 10.1021/bi700752n