Thomas, Sophie R., Bonsignore, Riccardo ![]() ![]() |
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Official URL: http://dx.doi.org/10.1002/cbic.202000262
Abstract
To gain more insight into the factors controlling the efficient cysteine arylation by cyclometalated Au(III) complexes, the reaction between selected gold compounds and different peptides was investigated by high‐resolution liquid chromatography electrospray ionization mass spectrometry (HR‐LC‐ESI‐MS). The deducted mechanisms of C–S cross‐coupling, also supported by density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced the key role of secondary peptidic gold binding sites in favouring the process of reductive elimination.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | Wiley |
ISSN: | 1439-4227 |
Funders: | EPSRC, BBSRC, Leverhulme Trust and the Royal Society |
Date of First Compliant Deposit: | 23 June 2020 |
Date of Acceptance: | 8 June 2020 |
Last Modified: | 05 Jan 2024 07:44 |
URI: | https://orca.cardiff.ac.uk/id/eprint/132734 |
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