Hollow silicon microneedle fabrication using advanced plasma etch technologies for applications in transdermal drug delivery

Bolton, Chris J. W., Howells, Olivia, Blayney, Gareth J., Eng, Pey F., Birchall, James C. ORCID: https://orcid.org/0000-0001-8521-6924, Gualeni, Benedetta ORCID: https://orcid.org/0000-0002-5216-1151, Roberts, Kerry, Ashraf, Huma and Guy, Owen J. 2020. Hollow silicon microneedle fabrication using advanced plasma etch technologies for applications in transdermal drug delivery. Lab on a Chip 20 (15) , pp. 2788-2795. 10.1039/D0LC00567C

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Abstract

A novel production process flow is presented here for the manufacture of hollow silicon microneedles using deep reactive-ion etching (DRIE) technology. The patent-pending three-step process flow has been developed to produce multiple arrays of sharp-tipped, hollow microneedles, which facilitate easy insertion and controlled fluid injection into excised skin samples. A bevelled tip and vertical sidewalls for the microneedle have been achieved with good uniformity, despite >45% open etch area. Processing steps and etch challenges are discussed, and preliminary skin testing results are presented, showing effective needle insertion and delivery of fluorescent dye into ex vivo skin from human breast tissue.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Royal Society of Chemistry
ISSN:	1473-0197
Date of First Compliant Deposit:	8 July 2020
Date of Acceptance:	20 June 2020
Last Modified:	06 May 2023 11:02
URI:	https://orca.cardiff.ac.uk/id/eprint/133238

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