Dual role for phenylalanine 178 during catalysis by aristolochene synthase

Forcat, Silvia and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Dual role for phenylalanine 178 during catalysis by aristolochene synthase. Chemical Communications (18) , pp. 2094-2095. 10.1039/b407932a

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Abstract

A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of α- and β-farnesene as well as α and β-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry Research Institutes & Centres > Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Publisher:	RSC Publishing
ISSN:	1359-7345
Last Modified:	18 Oct 2022 13:19
URI:	https://orca.cardiff.ac.uk/id/eprint/13486

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