Assessment of a self-assembling peptide gel, SPG-178, in providing a clear operative field for trabeculectomy surgery for glaucoma in an animal model

Matsushita, Kenji, Kawashima, Rumi, Uesugi, Koji, Okada, Haruka, Sakaguchi, Hirokazu, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120 and Nishida, Kohji 2020. Assessment of a self-assembling peptide gel, SPG-178, in providing a clear operative field for trabeculectomy surgery for glaucoma in an animal model. Scientific Reports 10 (1) , 11326. 10.1038/s41598-020-68171-3

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Abstract

The presence of blood during ophthalmic surgery is problematic, as it can obstruct a surgeon’s view of the operative field. This is particularly true when performing trabeculectomy surgery to enhance ocular fluid outflow and reduce intraocular pressure as a treatment for glaucoma, one of the most common vision loss conditions worldwide. In this study, we investigated the performance of a transparent, self-assembling peptide gel (SPG-178) and its ability to maintain visibility during trabeculectomy surgery. Unlike the hyaluronic acid gel commonly used in ophthalmic surgery, SPG-178 did not permit the ingress of blood into the gel itself. Rather, it forced blood to flow peripherally to the gel. Moreover, if bleeding occurred under the SPG-178 gel, perfusion with saline was able to effectively flush the blood away along the interface between the SPG-178 and the ocular tissue (in this case scleral) to clear the surgical field of view. In experimental trabeculectomy surgeries with mitomycin C used as an adjuvant, there were no differences in the postoperative recovery of intraocular pressure or bleb morphology with or without the use of SPG-178. SPG-178, therefore, when used in a gel formulation, represents a new material for use in intraocular surgery to ensure a clear operative field with likely beneficial treatment outcomes.

Item Type:	Article
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	28 September 2020
Last Modified:	15 May 2023 05:01
URI:	https://orca.cardiff.ac.uk/id/eprint/135134

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