Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.

Hiller, LaDeana W., International Chicken Genome Sequencing Consortium and Webber, Caleb ORCID: https://orcid.org/0000-0001-8063-7674 2004. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432 , pp. 659-716. 10.1038/nature03154

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Abstract

We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	0028-0836
Date of Acceptance:	1 November 2004
Last Modified:	09 Nov 2022 09:27
URI:	https://orca.cardiff.ac.uk/id/eprint/135789

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