Satellitosis, a crosstalk between neurons, vascular structures and neoplastic cells in brain tumours; early manifestation of invasive behaviour

Civita, Prospero, Valerio, Ortenzi, Naccarato, Antonio Giuseppe, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Pilkington, Geoffrey J. 2020. Satellitosis, a crosstalk between neurons, vascular structures and neoplastic cells in brain tumours; early manifestation of invasive behaviour. Cancers 12 (12) , 3720. 10.3390/cancers12123720

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Abstract

The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognised as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow–Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. At the same time, we review the current knowledge about the role of perineuronal satellitosis and perivascular satellitosis within the tumour microenvironment (TME), in order to highlight critical knowledge gaps in research space.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Additional Information:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Publisher:	MDPI
ISSN:	2072-6694
Date of First Compliant Deposit:	15 December 2020
Date of Acceptance:	4 December 2020
Last Modified:	27 Oct 2023 06:19
URI:	https://orca.cardiff.ac.uk/id/eprint/137041

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