Protein lysine methyltransferase G9a acts on non-histone targets

Rathert, Philipp, Dhayalan, Arunkumar, Murakami, Marie, Zhang, Xing, Tamas, Raluca, Jurkowska, Renata ORCID: https://orcid.org/0000-0002-4507-2222, Komatsu, Yasuhiko, Shinkai, Yoichi, Cheng, Xiaodong and Jeltsch, Albert 2008. Protein lysine methyltransferase G9a acts on non-histone targets. Nature Chemical Biology 4 (6) , 344–346. 10.1038/nchembio.88

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Abstract

By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Nature Research
ISSN:	1552-4450
Date of Acceptance:	3 April 2008
Last Modified:	09 Nov 2022 10:22
URI:	https://orca.cardiff.ac.uk/id/eprint/139263

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