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Protein lysine methyltransferase G9a acts on non-histone targets

Rathert, Philipp, Dhayalan, Arunkumar, Murakami, Marie, Zhang, Xing, Tamas, Raluca, Jurkowska, Renata ORCID:, Komatsu, Yasuhiko, Shinkai, Yoichi, Cheng, Xiaodong and Jeltsch, Albert 2008. Protein lysine methyltransferase G9a acts on non-histone targets. Nature Chemical Biology 4 (6) , 344–346. 10.1038/nchembio.88

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By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Nature Research
ISSN: 1552-4450
Date of Acceptance: 3 April 2008
Last Modified: 09 Nov 2022 10:22

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