Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type

Dennison, Charlotte ORCID: https://orcid.org/0000-0002-7493-2041, Legge, Sophie, Hubbard, Leon, Lynham, Amy ORCID: https://orcid.org/0000-0002-3189-6888, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Cardno, Alastair, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47 (5) , pp. 1375-1384. 10.1093/schbul/sbab036

PDF - Published Version Available under License Creative Commons Attribution. Download (594kB)

Abstract

There is controversy about the status of schizoaffective disorder depressive-type (SA-D), particularly whether it should be considered a form of schizophrenia or a distinct disorder. We aimed to determine whether individuals with SA-D differ from individuals with schizophrenia in terms of demographic, premorbid, and lifetime clinical characteristics, and genetic liability to schizophrenia, depression, and bipolar disorder. Participants were from the CardiffCOGS sample and met ICD-10 criteria for schizophrenia (n = 713) or SA-D (n = 151). Two samples, Cardiff Affected-sib (n = 354) and Cardiff F-series (n = 524), were used for replication. For all samples, phenotypic data were ascertained through structured interview, review of medical records, and an ICD-10 diagnosis made by trained researchers. Univariable and multivariable logistic regression models were used to compare individuals with schizophrenia and SA-D for demographic and clinical characteristics, and polygenic risk scores (PRS). In the CardiffCOGS, SA-D, compared to schizophrenia, was associated with female sex, childhood abuse, history of alcohol dependence, higher functioning Global Assessment Scale (GAS) score in worst episode of psychosis, lower functioning GAS score in worst episode of depression, and reduced lifetime severity of disorganized symptoms. Individuals with SA-D had higher depression PRS compared to those with schizophrenia. PRS for schizophrenia and bipolar disorder did not significantly differ between SA-D and schizophrenia. Compared to individuals with schizophrenia, individuals with SA-D had higher rates of environmental and genetic risk factors for depression and a similar genetic liability to schizophrenia. These findings are consistent with SA-D being a sub-type of schizophrenia resulting from elevated liability to both schizophrenia and depression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Oxford University Press
ISSN:	0586-7614
Funders:	MRC
Date of First Compliant Deposit:	29 March 2021
Date of Acceptance:	13 March 2021
Last Modified:	17 Jan 2024 02:22
URI:	https://orca.cardiff.ac.uk/id/eprint/140173

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item