Bagley, Mark Christopher, Davis, Terence  ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew Charles, Widdowson, Caroline S. and Kipling, David Glyn
2006.
Microwave-assisted synthesis of N-pyrazole ureas and the p38 inhibitor BIRB 796 for study into accelerated cell ageing.
Organic & biomolecular chemistry
4
(22)
, pp. 4158-4164.
10.1039/b611493h
|
Abstract
Microwave irradiation of substituted hydrazines and -ketoesters gives 5-aminopyrazoles in excellent yield, which can be transformed to the corresponding N-carbonyl derivatives by treatment with an isocyanate or chloroformate. Derivatization of 4-nitronaphth-1-ol using predominantly microwave heating methods and reaction with an N-pyrazole carbamate provides a rapid route to the N-pyrazole urea BIRB 796 in high purity, as a potent and selective inhibitor of p38 mitogen-activated protein kinase for the study of accelerated ageing in Werner syndrome cells.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Schools > Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 14770520 |
| Last Modified: | 14 Dec 2022 02:13 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/1423 |
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