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Circadian rhythm modulation of microbes during health and infection

Pearson, James Alexander ORCID:, Voisey, Alexander Christopher ORCID:, Boest Bjerg, Kathrine, Wong, F. Susan ORCID: and Wen, Li 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12 , 721004. 10.3389/fmicb.2021.721004

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Circadian rhythms, referring to 24-h daily oscillations in biological and physiological processes, can significantly regulate host immunity to pathogens, as well as commensals, resulting in altered susceptibility to disease development. Furthermore, vaccination responses to microbes have also shown time-of-day-dependent changes in the magnitude of protective immune responses elicited in the host. Thus, understanding host circadian rhythm effects on both gut bacteria and viruses during infection is important to minimize adverse effects on health and identify optimal times for therapeutic administration to maximize therapeutic success. In this review, we summarize the circadian modulations of gut bacteria, viruses and their interactions, both in health and during infection. We also discuss the importance of chronotherapy (i.e., timespecific therapy) as a plausible therapeutic administration strategy to enhance beneficial therapeutic responses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
Publisher: Frontiers Media
ISSN: 1664-302X
Funders: MRC
Date of First Compliant Deposit: 9 September 2021
Date of Acceptance: 5 August 2021
Last Modified: 18 May 2023 14:46

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