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Regulatory B cells in type 1 diabetes

Boldison, Joanne, Da Rosa, Larissa Camargo and Wong, F. Susan 2021. Regulatory B cells in type 1 diabetes. In: Mion, Francesca and Tonon, Silvia eds. Regulatory B Cells, Vol. 2270. Methods in Molecular Biology, New York, US: Humana Press, pp. 419-435. (10.1007/978-1-0716-1237-8_22)

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Type 1 diabetes is an organ-specific autoimmune disease characterized by immune-mediated beta cell destruction in pancreatic islets, which results in deficient insulin production. B cells have a dual role in type 1 diabetes pathogenesis. A pathogenic role for B cells has been widely described and is supported by the observation of a delay in the loss of C-peptide following B-cell depletion by Rituximab, in the first year after diagnosis. However, it is now clear that B cells, under certain conditions, can delay and prevent the onset of type 1 diabetes as demonstrated in mouse models. In this chapter, we describe the methods required to study the phenotype and function of regulatory B cells in the context of diabetes.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Humana Press
ISBN: 9781071612378
ISSN: 1064-3745
Last Modified: 13 Sep 2021 09:30

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