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Using methylcholanthrene-induced fibrosarcomas to study tumor immunology

Lauder, S. N., Milutinovic, S. ORCID:, Pires, A., Smart, K., Godkin, A. ORCID: and Gallimore, A. ORCID: 2021. Using methylcholanthrene-induced fibrosarcomas to study tumor immunology. Methods in Cell Biology, Vol. 163. Elsevier, pp. 59-75. (10.1016/bs.mcb.2020.09.007)

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Mouse models of cancer are essential in furthering our understanding both of the mechanisms that drive tumor development and the immune response that develops in parallel, and also in providing a platform for testing novel anti-cancer therapies. The majority of solid tumor models available rely on the injection of existing cancer cell lines into naïve hosts which, while providing quick and reproducible model systems, typically lack the development of a tumor microenvironment that recapitulates those seen in human cancers. Administration of the carcinogen 3-methylcholanthrene (MCA), allows tumors to develop in situ, forming a tumor microenvironment with an established stroma and vasculature. This article provides a detailed set of protocols for the administration of MCA into mice and the subsequent monitoring of tumors. Protocols are also provided for some of the routinely used downstream applications that can be used for MCA tumors.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISBN: 9780128225349
ISSN: 0091-679X
Date of First Compliant Deposit: 10 September 2021
Last Modified: 29 Nov 2022 09:35

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